Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Feb 25:2020:5734539.
doi: 10.1155/2020/5734539. eCollection 2020.

Tissue Engineering Approaches for Enamel, Dentin, and Pulp Regeneration: An Update

Geraldine M Ahmed  1   2 , Eman A Abouauf  1   3 , Nermeen AbuBakr  1   4 , Christof E Dörfer  5 , Karim Fawzy El-Sayed  1   5   6
Affiliations
Review

Tissue Engineering Approaches for Enamel, Dentin, and Pulp Regeneration: An Update

Geraldine M Ahmed et al. Stem Cells Int. .

Abstract

Stem/progenitor cells are undifferentiated cells characterized by their exclusive ability for self-renewal and multilineage differentiation potential. In recent years, researchers and investigations explored the prospect of employing stem/progenitor cell therapy in regenerative medicine, especially stem/progenitor cells originating from the oral tissues. In this context, the regeneration of the lost dental tissues including enamel, dentin, and the dental pulp are pivotal targets for stem/progenitor cell therapy. The present review elaborates on the different sources of stem/progenitor cells and their potential clinical applications to regenerate enamel, dentin, and the dental pulpal tissues.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Diagram showing cells, growth factors, and scaffolds examined in the field of enamel regeneration.
Figure 2
Figure 2
Diagram showing cells, growth factors, and scaffolds examined in the field of dentin regeneration.
Figure 3
Figure 3
Diagram showing cells, growth factors, and scaffolds examined in the field of pulp regeneration.
See this image and copyright information in PMC

References

    1. Setzer F. C., Kim S. Comparison of long-term survival of implants and endodontically treated teeth. Journal of Dental Research. 2014;93(1):19–26. doi: 10.1177/0022034513504782. - DOI - PMC - PubMed
    1. Zhu H., Guo Z. K., Jiang X. X., et al. A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone. Nature Protocols. 2010;5(3):550–560. doi: 10.1038/nprot.2009.238. - DOI - PubMed
    1. Lv F.-J., Tuan R. S., Cheung K. M. C., Leung V. Y. L. Concise review: the surface markers and identity of human mesenchymal stem cells. Stem Cells. 2014;32(6):1408–1419. doi: 10.1002/stem.1681. - DOI - PubMed
    1. Fawzy El-Sayed K. M., Dorfer C., Fandrich F., Gieseler F., Moustafa M. H., Ungefroren H. Mesenchymal Stem Cells - Basics and Clinical Application II. Vol. 130. Springer; 2013. Erratum to: Adult mesenchymal stem cells explored in the dental field; pp. 301–302. (Advances in Biochemical Engineering/Biotechnology). - DOI - PubMed
    1. Fawzy El-Sayed K. M., Dorfer C., Fandrich F., Gieseler F., Moustafa M. H., Ungefroren H. Mesenchymal Stem Cells - Basics and Clinical Application II. Advances in Biochemical Engineering/Biotechnology, vol 130. Berlin, Heidelberg: Springer; 2013. Adult mesenchymal stem cells explored in the dental field; pp. 89–103. - DOI - PubMed

LinkOut - more resources