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. 2020 Jan 14;11(3):228-231.
doi: 10.1021/acsmedchemlett.9b00582. eCollection 2020 Mar 12.

New Chemical Modalities and Strategic Thinking in Early Drug Discovery

Maria-Jesus Blanco  1 , Kevin M Gardinier  2
Affiliations

New Chemical Modalities and Strategic Thinking in Early Drug Discovery

Maria-Jesus Blanco et al. ACS Med Chem Lett. .

Abstract

The classical toolbox for drug discovery is continuously expanding beyond traditional small molecules. New chemical modalities including RNA therapeutics, protein degraders, cyclopeptides, antibody drug conjugates, and gene therapy have matured, demonstrating clinical success and are now considered early in target appraisal. In this Viewpoint, we highlight recent progress in the field.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Representation of three cornerstones of target validation and opportunities within the chemical modality toolbox.
See this image and copyright information in PMC

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