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. 2020 Mar 12;11(3):237-240.
doi: 10.1021/acsmedchemlett.9b00597.

PROTAC Technology: Opportunities and Challenges

Hongying Gao  1   2 , Xiuyun Sun  1   2 , Yu Rao  1
Affiliations

PROTAC Technology: Opportunities and Challenges

Hongying Gao et al. ACS Med Chem Lett. .

Abstract

PROTACs-induced targeted protein degradation has emerged as a novel therapeutic strategy in drug development and attracted the favor of academic institutions, large pharmaceutical enterprises (e.g., AstraZeneca, Bayer, Novartis, Amgen, Pfizer, GlaxoSmithKline, Merck, and Boehringer Ingelheim, etc.), and biotechnology companies. PROTACs opened a new chapter for novel drug development. However, any new technology will face many new problems and challenges. Perspectives on the potential opportunities and challenges of PROTACs will contribute to the research and development of new protein degradation drugs and degrader tools.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Overview steps of entire target protein degradation by PROTACs. TP, target protein.
See this image and copyright information in PMC

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