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Case Reports
. 2020 Feb 5;8(3):498-503.
doi: 10.1002/ccr3.2666. eCollection 2020 Mar.

Antenatal diagnosis of absence of septum pellucidum

Imane Ben M'Barek  1 , Mikael Tassin  1 , Agnes Guët  2   3 , Isabelle Simon  4 , Valerie Mairovitz  1 , Laurent Mandelbrot  1 , Olivier Picone  1
Affiliations
Case Reports

Antenatal diagnosis of absence of septum pellucidum

Imane Ben M'Barek et al. Clin Case Rep. .

Abstract

The absence of septum pellucidum (ASP) is a rare disease, which affects the structure of the brain. It is either isolated or associated with various congenital brain malformations. The diagnosis of ASP can be performed by second-trimester ultrasound. When the ASP is isolated, prenatal counseling is optimistic regarding neurological outcome, but there is a 20% risk of septo-optic dysplasia in the neonate.

Keywords: Septal agenesis; Septum pellucidum; cerebral MRI; limbic system; prenatal diagnosis; septo‐optic dysplasia.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Coronal US performed at 26 WG and 6 d showing the square fused frontal horns
Figure 2
Figure 2
Axial section at 22 WG and 5 d. Anterior horns are merged
Figure 3
Figure 3
Axial US at 32 WG and 4 d. The wall of the ventricle can be mistaken for the columns of the fornix
Figure 4
Figure 4
Sagittal MRI performed at 32 WG. Short corpus callosum
Figure 5
Figure 5
T2‐weighted MRI at 32 WG, coronal view showing perisylvian microgyria on the right side
See this image and copyright information in PMC

References

    1. Callen PW, Callen AL, Glenn OA, Toi A. Columns of the fornix, not to be mistaken for the cavum septi pellucidi on prenatal sonography. J Ultrasound Med. 2008;27(1):25‐31. - PubMed
    1. Barkovich AJ, Norman D. Absence of the septum pellucidum: a useful sign in the diagnosis of congenital brain malformations. AJR Am J Roentgenol. 1989;152(2):353‐360. - PubMed
    1. Malinger G, Lev D, Kidron D, Heredia F, Hershkovitz R, Lerman‐Sagie T. Differential diagnosis in fetuses with absent septum pellucidum. Ultrasound Obstet Gynecol. 2005;25(1):42‐49. - PubMed
    1. Bruyn GW. Agenesis septi pellucidi, cavum septi pellucidi, cavum Vergae and cavum veli interpositi In: Vinken PJ, Bruyn GW, eds. Congenital Malformations of the Brain and Skull Part 1. Amsterdam, North Holland; 1977: 299‐336.
    1. Schaefer GB, Bodensteiner JB, Thompson JN. Subtle anomalies of the septum pellucidum and neurodevelopmental deficits. Dev Med Child Neurol. 1994;36(6):554‐559. - PubMed

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