Update on Sjögren's Syndrome 2018

doi:10.31138/mjr.29.4.193

Review

. 2018 Dec 18;29(4):193-198.

doi: 10.31138/mjr.29.4.193. eCollection 2018 Dec.

Update on Sjögren's Syndrome 2018

Ourania D Argyropoulou¹, Athanasios G Tzioufas¹

Affiliations

PMID: 32185326
PMCID: PMC7045943
DOI: 10.31138/mjr.29.4.193

Review

Update on Sjögren's Syndrome 2018

Ourania D Argyropoulou et al. Mediterr J Rheumatol. 2018.

. 2018 Dec 18;29(4):193-198.

doi: 10.31138/mjr.29.4.193. eCollection 2018 Dec.

Authors

Ourania D Argyropoulou¹, Athanasios G Tzioufas¹

Affiliation

¹ Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Greece.

PMID: 32185326
PMCID: PMC7045943
DOI: 10.31138/mjr.29.4.193

Abstract

Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease with a diverse clinical picture, extending from exocrine involvement to extraglandular manifestations. Although pSS remains a disease of unknown etiology, an interaction between genetic susceptibility and environmental triggers is thought to play a key role in disease initiation and progress. Despite the extensive research during the past years, the pathogenetic mechanisms are still elusive and effective therapeutic intervention is still missing. This review aims to provide an overview of the recent literature on the pathogenesis, clinical features and new therapeutic aspects of pSS.

Keywords: Sjögren’s syndrome; germinal centers; pathogenesis; salivary gland ultrasonography; treatment.

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References

1. Mavragani CP . Mechanisms and New Strategies for Primary Sjögren’s Syndrome. Ann Rev Med 2017. ; 68 : 331 – 43 . [ 10.1146/annurev-med-043015-123313 ] [PMID: ] - DOI - PubMed
1. Fogel O, Rivière E, Seror R, Nocturne G, Boudaoud S, Ly B, et al. . Role of the IL-12/IL35 balance in patients with Sjögren syndrome. J Allergy Clin Immunol 2018; 142:258–68. [ 10.1016/j.jaci.2017.07.041 ] [PMID: ] - DOI - PubMed
1. Nilsson AM, Tufvesson E, Hesselstrand R, Olsson P, Wollmer P, Mandl T . Increased B-cell activating factor, interleukin-6, and interleukin-8 in induced sputum from primary Sjögren’s syndrome patients . Scand J Rheumatol 2018. September 30 : 1 – 8 . [Epub ahead of print]. [ 10.1080/03009742.2018.1473488 ] [PMID: ] - DOI - PubMed
1. Lessard CJ1, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, et al. . Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren’s syndrome. Nat Genet 2013. ; 45 : 1284 – 92 . [ 10.1038/ng.2792 ] [PMID: ] [PMCID: ] - DOI - PMC - PubMed
1. Argyropoulou OD, Valentini E, Ferro F, Leone MC, Cafaro G, Bartoloni E, Baldini C . One year in review 2018; Sjögren’s syndrome. Clin Exp Rheumatol 2018. ; 36 ( Suppl. 112 ): 14 – 26 . - PubMed

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[1] Mavragani CP . Mechanisms and New Strategies for Primary Sjögren’s Syndrome. Ann Rev Med 2017. ; 68 : 331 – 43 . [ 10.1146/annurev-med-043015-123313 ] [PMID: ] - DOI - PubMed

[2] Mavragani CP . Mechanisms and New Strategies for Primary Sjögren’s Syndrome. Ann Rev Med 2017. ; 68 : 331 – 43 . [ 10.1146/annurev-med-043015-123313 ] [PMID: ] - DOI - PubMed

[3] Fogel O, Rivière E, Seror R, Nocturne G, Boudaoud S, Ly B, et al. . Role of the IL-12/IL35 balance in patients with Sjögren syndrome. J Allergy Clin Immunol 2018; 142:258–68. [ 10.1016/j.jaci.2017.07.041 ] [PMID: ] - DOI - PubMed

[4] Fogel O, Rivière E, Seror R, Nocturne G, Boudaoud S, Ly B, et al. . Role of the IL-12/IL35 balance in patients with Sjögren syndrome. J Allergy Clin Immunol 2018; 142:258–68. [ 10.1016/j.jaci.2017.07.041 ] [PMID: ] - DOI - PubMed

[5] Nilsson AM, Tufvesson E, Hesselstrand R, Olsson P, Wollmer P, Mandl T . Increased B-cell activating factor, interleukin-6, and interleukin-8 in induced sputum from primary Sjögren’s syndrome patients . Scand J Rheumatol 2018. September 30 : 1 – 8 . [Epub ahead of print]. [ 10.1080/03009742.2018.1473488 ] [PMID: ] - DOI - PubMed

[6] Nilsson AM, Tufvesson E, Hesselstrand R, Olsson P, Wollmer P, Mandl T . Increased B-cell activating factor, interleukin-6, and interleukin-8 in induced sputum from primary Sjögren’s syndrome patients . Scand J Rheumatol 2018. September 30 : 1 – 8 . [Epub ahead of print]. [ 10.1080/03009742.2018.1473488 ] [PMID: ] - DOI - PubMed

[7] Lessard CJ1, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, et al. . Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren’s syndrome. Nat Genet 2013. ; 45 : 1284 – 92 . [ 10.1038/ng.2792 ] [PMID: ] [PMCID: ] - DOI - PMC - PubMed

[8] Lessard CJ1, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, et al. . Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren’s syndrome. Nat Genet 2013. ; 45 : 1284 – 92 . [ 10.1038/ng.2792 ] [PMID: ] [PMCID: ] - DOI - PMC - PubMed

[9] Argyropoulou OD, Valentini E, Ferro F, Leone MC, Cafaro G, Bartoloni E, Baldini C . One year in review 2018; Sjögren’s syndrome. Clin Exp Rheumatol 2018. ; 36 ( Suppl. 112 ): 14 – 26 . - PubMed

[10] Argyropoulou OD, Valentini E, Ferro F, Leone MC, Cafaro G, Bartoloni E, Baldini C . One year in review 2018; Sjögren’s syndrome. Clin Exp Rheumatol 2018. ; 36 ( Suppl. 112 ): 14 – 26 . - PubMed

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Update on Sjögren's Syndrome 2018

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Update on Sjögren's Syndrome 2018

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