Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Dec 18;29(4):193-198.
doi: 10.31138/mjr.29.4.193. eCollection 2018 Dec.

Update on Sjögren's Syndrome 2018

Ourania D Argyropoulou  1 , Athanasios G Tzioufas  1
Affiliations
Review

Update on Sjögren's Syndrome 2018

Ourania D Argyropoulou et al. Mediterr J Rheumatol. .

Abstract

Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease with a diverse clinical picture, extending from exocrine involvement to extraglandular manifestations. Although pSS remains a disease of unknown etiology, an interaction between genetic susceptibility and environmental triggers is thought to play a key role in disease initiation and progress. Despite the extensive research during the past years, the pathogenetic mechanisms are still elusive and effective therapeutic intervention is still missing. This review aims to provide an overview of the recent literature on the pathogenesis, clinical features and new therapeutic aspects of pSS.

Keywords: Sjögren’s syndrome; germinal centers; pathogenesis; salivary gland ultrasonography; treatment.

PubMed Disclaimer

References

    1. Mavragani CP . Mechanisms and New Strategies for Primary Sjögren’s Syndrome. Ann Rev Med 2017. ; 68 : 331 – 43 . [ 10.1146/annurev-med-043015-123313 ] [PMID: ] - DOI - PubMed
    1. Fogel O, Rivière E, Seror R, Nocturne G, Boudaoud S, Ly B, et al. . Role of the IL-12/IL35 balance in patients with Sjögren syndrome. J Allergy Clin Immunol 2018; 142:258–68. [ 10.1016/j.jaci.2017.07.041 ] [PMID: ] - DOI - PubMed
    1. Nilsson AM, Tufvesson E, Hesselstrand R, Olsson P, Wollmer P, Mandl T . Increased B-cell activating factor, interleukin-6, and interleukin-8 in induced sputum from primary Sjögren’s syndrome patients . Scand J Rheumatol 2018. September 30 : 1 – 8 . [Epub ahead of print]. [ 10.1080/03009742.2018.1473488 ] [PMID: ] - DOI - PubMed
    1. Lessard CJ1, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, et al. . Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren’s syndrome. Nat Genet 2013. ; 45 : 1284 – 92 . [ 10.1038/ng.2792 ] [PMID: ] [PMCID: ] - DOI - PMC - PubMed
    1. Argyropoulou OD, Valentini E, Ferro F, Leone MC, Cafaro G, Bartoloni E, Baldini C . One year in review 2018; Sjögren’s syndrome. Clin Exp Rheumatol 2018. ; 36 ( Suppl. 112 ): 14 – 26 . - PubMed

LinkOut - more resources