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Review
. 2020 Apr;22(4):e13186.
doi: 10.1111/cmi.13186.

Listeria monocytogenes, a model in infection biology

Marc Lecuit  1   2   3   4   5
Affiliations
Free article
Review

Listeria monocytogenes, a model in infection biology

Marc Lecuit. Cell Microbiol. 2020 Apr.
Free article

Abstract

Listeria monocytogenes causes listeriosis, a systemic infection which manifests as bacteremia, often complicated by meningoencephalitis in immunocompromised individuals and the elderly, and fetal-placental infection in pregnant women. It has emerged over the past decades as a major foodborne pathogen, responsible for numerous outbreaks in Western countries, and more recently in Africa. L. monocytogenes' pathogenic properties have been studied in detail, thanks to concomitant advances in biological sciences, in particular molecular biology, cell biology and immunology. L. monocytogenes has also been instrumental to basic advances in life sciences. L. monocytogenes therefore stands both a tool to understand biology and a model in infection biology. This review briefly summarises the clinical and some of the pathophysiological features of listeriosis. In the context of this special issue, it highlights some of the major discoveries made by Pascale Cossart in the fields of molecular and cellular microbiology since the mid-eighties regarding the identification and characterisation of multiple bacterial and host factors critical to L. monocytogenes pathogenicity. It also briefly summarises some of the key findings from our laboratory on this topic over the past years.

Keywords: Listeria; animal model; biology; cell biology; infection; pathogenesis.

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References

REFERENCES

    1. Aureli, P., Fiorucci, G. C., Caroli, D., Marchiaro, G., Novara, O., Leone, L., & Salmaso, S. (2000). An outbreak of febrile gastroenteritis associated with corn contaminated by Listeria monocytogenes. The New England Journal of Medicine, 342(17), 1236-1241. https://doi.org/10.1056/NEJM200004273421702
    1. Bakardjiev, A. I., Stacy, B. A., Fisher, S. J., & Portnoy, D. A. (2004). Listeriosis in the pregnant Guinea pig: A model of vertical transmission. Infection and Immunity, 72(1), 489-497.
    1. Bakardjiev, A. I., Theriot, J. A., & Portnoy, D. A. (2006). Listeria monocytogenes traffics from maternal organs to the placenta and back. PLoS Pathogens, 2(6), e66. https://doi.org/10.1371/journal.ppat.0020066
    1. Bleriot, C., Dupuis, T., Jouvion, G., Eberl, G., Disson, O., & Lecuit, M. (2015). Liver-resident macrophage necroptosis orchestrates type 1 Microbicidal inflammation and Type-2-mediated tissue repair during bacterial infection. Immunity, 42(1), 145-158. https://doi.org/10.1016/j.immuni.2014.12.020
    1. Bonazzi, M., Veiga, E., Pizarro-Cerda, J., & Cossart, P. (2008). Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes. Cellular Microbiology, 10(11), 2208-2222. https://doi.org/10.1111/j.1462-5822.2008.01200.x

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