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Comment
. 2020 Mar 17;52(3):426-428.
doi: 10.1016/j.immuni.2020.02.011.

A Tuft Act to Follow: Leukotrienes Take the Stage in Anti-worm Immunity

Connie Fung  1 , Michael R Howitt  2
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A Tuft Act to Follow: Leukotrienes Take the Stage in Anti-worm Immunity

Connie Fung et al. Immunity. .
Free article

Abstract

Tuft cells are specialized taste-chemosensory cells that detect the presence of intestinal parasites and orchestrate type 2 immunity. In this issue of Immunity, McGinty et al. discover that parasitic worms, but not commensal protists, stimulate tuft cells to release cysteinyl leukotrienes to amplify anti-helminth immunity in the small intestine.

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