Mitochondrial Complex I Inhibition by Metformin: Drug-Exercise Interactions

S Martín-Rodríguez¹, P de Pablos-Velasco², J A L Calbet³

Affiliations

¹ Department of Physical Education, University of Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), 35017 Las Palmas de Gran Canaria, Spain. Electronic address: saulmrguez@gmail.com.
² Research Institute of Biomedical and Health Sciences (IUIBS), 35017 Las Palmas de Gran Canaria, Spain; Department of Endocrinology and Nutrition, Hospital Universitario de Gran Canaria Doctor Negrín, 35010 Las Palmas de Gran Canaria, Spain.
³ Department of Physical Education, University of Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), 35017 Las Palmas de Gran Canaria, Spain; Department of Physical Performance, Norwegian School of Sport Sciences, Postboks, 4014 Ulleval Stadion, 0806 Oslo, Norway.

PMID: 32187522
DOI: 10.1016/j.tem.2020.02.003

Comment

Mitochondrial Complex I Inhibition by Metformin: Drug-Exercise Interactions

S Martín-Rodríguez et al. Trends Endocrinol Metab. 2020 Apr.

. 2020 Apr;31(4):269-271.

doi: 10.1016/j.tem.2020.02.003. Epub 2020 Feb 20.

Authors

S Martín-Rodríguez¹, P de Pablos-Velasco², J A L Calbet³

Affiliations

¹ Department of Physical Education, University of Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), 35017 Las Palmas de Gran Canaria, Spain. Electronic address: saulmrguez@gmail.com.
² Research Institute of Biomedical and Health Sciences (IUIBS), 35017 Las Palmas de Gran Canaria, Spain; Department of Endocrinology and Nutrition, Hospital Universitario de Gran Canaria Doctor Negrín, 35010 Las Palmas de Gran Canaria, Spain.
³ Department of Physical Education, University of Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), 35017 Las Palmas de Gran Canaria, Spain; Department of Physical Performance, Norwegian School of Sport Sciences, Postboks, 4014 Ulleval Stadion, 0806 Oslo, Norway.

PMID: 32187522
DOI: 10.1016/j.tem.2020.02.003

Abstract

Metformin has antidiabetic, anticancer, and prolongevity effects, but seems to interfere with aerobic training mitochondrial adaptations. The primary mechanism of action has been suggested to be the inhibition of mitochondrial complex I. Recent papers (Wang et al. and Cameron et al.), however, provide evidence to deny the hypothesis of a direct action of metformin on complex I.

Keywords: exercise; metformin; mitochondrial complex I.

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Metformin selectively targets redox control of complex I energy transduction.
Cameron AR, Logie L, Patel K, Erhardt S, Bacon S, Middleton P, Harthill J, Forteath C, Coats JT, Kerr C, Curry H, Stewart D, Sakamoto K, Repiščák P, Paterson MJ, Hassinen I, McDougall G, Rena G. Cameron AR, et al. Redox Biol. 2018 Apr;14:187-197. doi: 10.1016/j.redox.2017.08.018. Epub 2017 Aug 26. Redox Biol. 2018. PMID: 28942196 Free PMC article.
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK.
Wang Y, An H, Liu T, Qin C, Sesaki H, Guo S, Radovick S, Hussain M, Maheshwari A, Wondisford FE, O'Rourke B, He L. Wang Y, et al. Cell Rep. 2019 Nov 5;29(6):1511-1523.e5. doi: 10.1016/j.celrep.2019.09.070. Cell Rep. 2019. PMID: 31693892 Free PMC article.

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Mitochondrial Complex I Inhibition by Metformin: Drug-Exercise Interactions

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Mitochondrial Complex I Inhibition by Metformin: Drug-Exercise Interactions

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