Acromegaly and Vertebral Fractures: Facts and Questions

Abstract

Here I review vertebral fractures (VFs) as an emerging complication of acromegaly through a pathway of key questions in order to help clinicians manage the disease. Peculiarities of acromegalic osteopathy are that VFs are common but not explained by low bone mineral density (BMD) being related to disease duration and activity, and occurring even after remission.

Keywords: acromegaly; bone; growth hormone; insulin-like growth factor 1; morphometry; vertebral fractures.