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. 2020 Apr;21(4):222-229.
doi: 10.1111/1751-2980.12858. Epub 2020 Apr 21.

The relationship between gastric cancer, its precancerous lesions and bile reflux: A retrospective study

Dan Li  1 , Jian Zhang  2 , Wen Zhu Yao  1 , Dong Lin Zhang  3 , Chen Chen Feng  1 , Qi He  1 , Huan Huan Lv  1 , Ya Ping Cao  1 , Jie Wang  1 , Ying Qi  1 , Si Ran Wu  2 , Na Wang  2 , Jing Zhao  4 , Yong Quan Shi  1   2
Affiliations

The relationship between gastric cancer, its precancerous lesions and bile reflux: A retrospective study

Dan Li et al. J Dig Dis. 2020 Apr.

Abstract

Objective: To evaluate the relationship between gastric cancer (GC) and precancerous lesions and bile reflux.

Methods: Medical records of 30 465 participants who underwent gastroscopy between January and December 2018 in our center were reviewed. Their age, sex, time of endoscopy, endoscopic/histologic diagnosis and grade of bile reflux were recorded. The participants were further divided into the chronic gastritis group (n = 27 807), a precancerous lesion group (n = 1943) and a GC group (n = 715). The χ2 tests and hierarchical analyses were performed.

Results: Patients aged 18-27 years had a higher bile reflux rate than those aged 28-37 and 68-75 years (P < 0.001), while it did not differ between patients aged <50 years and those over 50 years (P = 0.639). It was lower in men than in women (P < 0.001). The bile reflux rate did not differ in terms of months, seasons and half of the year (all P > 0.05), but differed between morning and afternoon when they underwent the endoscopy (P = 0.000). There was an interrelationship between the severity of gastric mucosal disease and bile reflux grade (r = 0.171). After excluding the effects of sex, age and time of endoscopy on bile reflux, bile reflux rate in chronic gastritis and precancerous lesions was lower than in gastric cancer (P < 0.01).

Conclusions: Bile reflux may be a risk factor for gastric cancer and precancerous lesions. A high grade of bile reflux may be associated with the progression of gastric mucosal diseases.

Keywords: bile reflux; gastric neoplasms; gastritis; intestinal metaplasia; precancerous lesions.

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Figures

FIGURE 1
FIGURE 1
Flowchart of participant enrollment
FIGURE 2
FIGURE 2
Grades of bile reflux. A, grade I bile reflux; B, grade II bile reflux; C, grade III bile reflux; and D, transient bile reflux [Color figure can be viewed at wileyonlinelibrary.com]
FIGURE 3
FIGURE 3
Relationship between bile reflux and age by comparing the rate of bile reflux among A, six different age groups and B, 18‐<50 years vs 50‐<75 years
FIGURE 4
FIGURE 4
Rates of bile reflux at A, different months; B, spring to winter; and C, Jan‐June and July‐Dec
See this image and copyright information in PMC

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