The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine

Abstract

Background: The increase of headache frequency is associated with higher headache related disability and lower quality of life in patients with migraine. However, the pathophysiology of migraine progression, persistence, or remission is elusive. The purpose of this study is to identify the brain signatures that are predictive of the long-term outcomes among patients with high-frequency migraine (HFM: 10-30 headache days/month).

Methods: We prospectively enrolled patients with HFM and healthy controls and collected their baseline clinical profiles and brain-MRI data at first visit. We longitudinally followed the patients and determined their outcomes at 2-year follow-up. Good outcome was defined as ≥50% reduction of baseline headache days and poor outcome was defined as reduction < 50% or frequency increase. Voxel-based morphometry was used to study gray matter volume (GMV), and structural covariance was used to investigate structural connectivity.

Results: Among 56 patients with HFM, 37 had good outcome and 19 poor outcome. Compared to the healthy controls (n = 37), patients with poor outcome had decreased GMV over the left posterior cingulate gyrus, and increased GMV over the bilateral cerebellum and the right precentral gyrus. Further, patients with poor outcome had greater GMV over the right and the left cerebella compared to patients with good outcome, and the GMVs of the cerebella were correlated to 2-year headache frequencies (right: r = 0.38, P = 0.005; left: r = 0.35, P = 0.009). Structural connectivity were increased between the cerebellum and the cuneus, the calcarine cortex, and the temporal lobe, respectively, in patients with poor outcome, and was decreased between the cerebellum and the prefrontal cortex in patients with poor outcome. The structural covariance integrities between the right cerebellum and the right cuneus were correlated to 2-year headache frequencies (r = 0.36, P = 0.008).

Conclusions: Structural volume and connectivity changes of the cerebellum may underlie headache persistence in patients with HFM.

Keywords: Cerebellum; High frequency; MRI; Migraine; Outcome.

Fig. 1

The red and blue markers are regions of different gray matter volume (a) between patients with high-frequency migraine (HFM) and healthy controls (HC); (b) between patients with poor outcome and HC; (c) between patients with different outcomes

Fig. 2

Three cerebellar seeds and the changes in the structural covariance (SC) network from the three seeds to the whole brain between patients with different outcomes. The blue and red markers are regions that displayed different SC with the seeds between the outcome groups