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. 2020 Mar 18;15(1):24.
doi: 10.1186/s13011-020-00266-6.

Effectiveness of naltrexone treatment for alcohol use disorders in HIV: a systematic review

Negin Farhadian  1 , Sajad Moradi  2 , Mohammad Hossein Zamanian  3   4 , Vahid Farnia  1 , Shahab Rezaeian  5 , Maryam Farhadian  6 , Mohsen Shahlaei  7
Affiliations

Effectiveness of naltrexone treatment for alcohol use disorders in HIV: a systematic review

Negin Farhadian et al. Subst Abuse Treat Prev Policy. .

Abstract

Background: Because alcohol use disorders (AUDs) in patients living with HIV/AIDS are associated with a reduction in therapeutic outcomes and increases the risk of morbidity/mortality, finding an appropriate pharmacotherapy treatment for this disorder is necessary.

Objectives: This systematic review contains studies that examine the effects of pharmacological intervention (oral naltrexone (NTX) or injectable extended-release naltrexone (XR-NTX)) on the persons living with HIV and AUDs.

Methods: A systematic literature search using three electronic databases including Pubmed Medline, Scopus and the Cochrane Library and Google Scholar was conducted and includes articles published from 1995 to 2019. Records were collected by searching relevant keywords and those that meet the inclusion/exclusion criteria are included.

Results: Overall, in this systematic review, the results of 7 relevant studies including pilot and randomized controlled/clinical trials were summarized and reviewed. Among selected records 2 of these assessed the efficacy of NTX and 5 tested the XR-NTX effectiveness in treating AUDs among persons living with HIV (PLH). In summary, with some expectations, NTX and XR-NTX administration in persons living with HIV and AUDs led to reduced alcohol use, improved viral suppression, unchanged ART adherence and has no significant adverse events.

Conclusion: The findings of this systematic review suggest the beneficial effects and safety of the NTX and XR-NTX for treating AUDs in PLH. Further studies are needed in the future to focus on the treatment of AUDs in people living with HIV.

Keywords: Alcohol use disorders (AUDs); HIV; Naltrexone; Systematic review; Treatment.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Searching strategy flow chart
See this image and copyright information in PMC

References

    1. da Silva CM, Mendoza-Sassi RA, da Mota LD, Nader MM, de Martinez AMB. Alcohol use disorders among people living with HIV/AIDS in southern Brazil: prevalence, risk factors and biological markers outcomes. BMC Infect Dis. 2017;17:263. doi: 10.1186/s12879-017-2374-0. - DOI - PMC - PubMed
    1. Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med. 2006;144:705–714. doi: 10.7326/0003-4819-144-10-200605160-00004. - DOI - PubMed
    1. Galvan FH, Bing EG, Fleishman JA, London AS, Caetano R, Burnam MA, Longshore D, Morton SC, Orlando M, Shapiro M. The prevalence of alcohol consumption and heavy drinking among people with HIV in the United States: results from the HIV cost and services utilization study. J Stud Alcohol. 2002;63:179–186. doi: 10.15288/jsa.2002.63.179. - DOI - PubMed
    1. Taylor AL, Denniston MM, Klevens RM, McKnight-Eily LR, Jiles RB. Association of hepatitis C virus with alcohol use among US adults: NHANES 2003–2010. Am J Prev Med. 2016;51:206–215. doi: 10.1016/j.amepre.2016.02.033. - DOI - PubMed
    1. Williams EC, Joo YS, Lipira L, Glass JE. Psychosocial stressors and alcohol use, severity, and treatment receipt across HIV status in a nationally representative sample of US residents. Subst Abus. 2017;38:269. doi: 10.1080/08897077.2016.1268238. - DOI - PMC - PubMed

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