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Observational Study
. 2020 Nov;50(11):4001-4010.
doi: 10.1007/s10803-020-04440-4.

An Observational Study of Social Interaction Skills and Behaviors in Cornelia de Lange, Fragile X and Rubinstein-Taybi Syndromes

Katherine Ellis  1   2   3 , Chris Oliver  4 , Chrysi Stefanidou  1   5 , Ian Apperly  6 , Jo Moss  1   3
Affiliations
Observational Study

An Observational Study of Social Interaction Skills and Behaviors in Cornelia de Lange, Fragile X and Rubinstein-Taybi Syndromes

Katherine Ellis et al. J Autism Dev Disord. 2020 Nov.

Abstract

We directly assessed the broader aspects of sociability (social enjoyment, social motivation, social interaction skills and social discomfort) in individuals with Cornelia de Lange (CdLS), fragile X (FXS) and Rubinstein-Taybi syndromes (RTS), and their association with autism characteristics and chronological age in these groups. Individuals with FXS (p < 0.01) and RTS (p < 0.01) showed poorer quality of eye contact compared to individuals with CdLS. Individuals with FXS showed less person and more object attention than individuals with CdLS (p < 0.01). Associations between sociability and autism characteristics and chronological age differed between groups, which may indicate divergence in the development and aetiology of different components of sociability across these groups. Findings indicate that individuals with CdLS, FXS and RTS show unique profiles of sociability.

Keywords: Eye gaze; Fragile X syndrome; Genetics behavioural; Neurodevelopmental disorders; Social behavior.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Median item scores on each CSRS item per syndrome
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