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Review
. 2020 May;102(5):934-939.
doi: 10.4269/ajtmh.19-0351.

Safety Considerations for Malaria Volunteer Infection Studies: A Mini-Review

Anand Odedra  1   2 , James S McCarthy  3   1
Affiliations
Review

Safety Considerations for Malaria Volunteer Infection Studies: A Mini-Review

Anand Odedra et al. Am J Trop Med Hyg. 2020 May.

Abstract

Malaria clinical studies entailing the experimental infection of healthy volunteers with Plasmodium parasites by bites from infected mosquitos, injection of cryopreserved sporozoites, or injection of blood-stage parasites provide valuable information for vaccine and drug development. Success of these studies depends on maintaining safety. In this mini-review, we discuss the safety risks and associated mitigation strategies of these three types of experimental malaria infection. We aimed to inform researchers and regulators who are currently involved in or are planning to establish experimental malaria infection studies in endemic or non-endemic settings.

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