Antimetastatic effect of amiloride in an animal tumour model
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Antimetastatic effect of amiloride in an animal tumour model
Anticancer Res.
1988 Nov-Dec.
Abstract
The diuretic Amiloride competitively inhibits the catalytic activity of the urokinase-type plasminogen activator on plasminogen in vitro. This effect was tested on a rat adenocarcinoma model and its invasive potential in the host lung. While the inhibitory effect on intact cell cultures of the tumour was slight, continuous exposure of tumour-injected animals to the drug completely prevented the formation of lung metastasis.
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