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. 1988 Nov-Dec;8(6):1373-6.

Antimetastatic effect of amiloride in an animal tumour model

J A Kellen  1 , A Mirakian, A Kolin
Affiliations
  • PMID: 3218971

Antimetastatic effect of amiloride in an animal tumour model

J A Kellen et al. Anticancer Res. 1988 Nov-Dec.

Abstract

The diuretic Amiloride competitively inhibits the catalytic activity of the urokinase-type plasminogen activator on plasminogen in vitro. This effect was tested on a rat adenocarcinoma model and its invasive potential in the host lung. While the inhibitory effect on intact cell cultures of the tumour was slight, continuous exposure of tumour-injected animals to the drug completely prevented the formation of lung metastasis.

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