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Case Reports
. 2020 Feb;24(Suppl 1):S33-S36.
doi: 10.4103/jomfp.JOMFP_17_20. Epub 2020 Feb 28.

Benign lymphoepithelial lesion of the minor salivary gland - A rare presentation as a palatal swelling

Chandrasekaran Krithika  1 , J Sreedevi  1 , B Sivapathasundharam  2 , V R Nithya  1
Affiliations
Case Reports

Benign lymphoepithelial lesion of the minor salivary gland - A rare presentation as a palatal swelling

Chandrasekaran Krithika et al. J Oral Maxillofac Pathol. 2020 Feb.

Abstract

Benign lymphoepithelial lesion (BLEL) is characterized by extensive lymphocytic infiltration of the major salivary glands and may be associated with Sjogren's syndrome or HIV infection. The involvement of the palatal minor salivary glands is extremely rare. We report an isolated case of BLEL affecting the palatal minor salivary glands, presenting as a palatal swelling in a 37-year-old female patient. Serological tests ruled out potential comorbid conditions. Cone-beam computed tomography showed a palatal soft-tissue mass with thinning of the adjacent cortical plates. A histopathological examination revealed salivary gland tissue with significant acinar destruction, dense lymphocytic infiltration and focal myoepithelial islands. Therefore, BLEL may be considered as a rare differential diagnostic possibility of a palatal soft-tissue mass lesion.

Keywords: Benign lymphoepithelial lesion; minor salivary gland; palate.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Intraoral photograph showing a single-diffuse swelling on the right side of the posterior hard palate with shallow superficial ulceration
Figure 2
Figure 2
Axial cone-beam computed tomography section showing a soft-tissue shadow in the right side of the hard palate
Figure 3
Figure 3
Coronal cone-beam computed tomography section showing thinning of the palatal cortical bone associated with a soft-tissue shadow on the right side
Figure 4
Figure 4
Low power view showing salivary gland acini and ductal structures exhibiting lymphocytic infiltration (H&E stain)
Figure 5
Figure 5
×10 magnification - salivary gland tissue showing significant acinar cell destruction and replacement with dense lymphocytic infiltration (H&E stain)
Figure 6
Figure 6
×40 magnification - high power view showing acinar cells, lymphocytic infiltrates and myoepithelial islands (H&E stain)
See this image and copyright information in PMC

References

    1. Schneider M, Rizzardi C. Lymphoepithelial carcinoma of the parotid glands and its relationship with benign lymphoepithelial lesions. Arch Pathol Lab Med. 2008;132:278–82. - PubMed
    1. Metwaly H, Cheng J, Suzuki M, Takata Y, Saitoh C, Hayashi T, et al. Benign lymphoepithelial lesion of minor salivary gland: Report of a case involving the palatal mucosa. Oral Oncol Extra. 2004;40:113–6.
    1. Yoshihara T, Morita M, Ishii T. Ultrastructure and three-dimensional imaging of epimyoepithelial islands in benign lymphoepithelial lesions. Eur Arch Otorhinolaryngol. 1995;252:106–11. - PubMed
    1. Chaudhry AP, Cutler LS, Yamane GM, Satchidanand S, Labay G, Sunderraj M. Light and ultrastructural features of lymphoepithelial lesions of the salivary glands in Mikulicz's disease. J Pathol. 1986;148:239–50. - PubMed
    1. Ihrler S, Zietz C, Sendelhofert A, Riederer A, Löhrs U. Lymphoepithelial duct lesions in Sjögren-type sialadenitis. Virchows Arch. 1999;434:315–23. - PubMed

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