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. 2020 Mar 1:2020:9149762.
doi: 10.1155/2020/9149762. eCollection 2020.

Role of Secreted Frizzled-Related Protein 1 and Tumor Necrosis Factor- α (TNF- α) in Bone Loss of Patients with Rheumatoid Arthritis

Andi Raga Ginting  1 , Rudy Hidayat  1 , Sumariyono Sumariyono  1 , Sukamto Koesnoe  2
Affiliations

Role of Secreted Frizzled-Related Protein 1 and Tumor Necrosis Factor- α (TNF- α) in Bone Loss of Patients with Rheumatoid Arthritis

Andi Raga Ginting et al. Int J Rheumatol. .

Abstract

Bone loss is one of the emerging extra-articular manifestations of rheumatoid arthritis. TNF-α is the main inflammatory cytokine that can directly increase bone resorption. However, its role in bone formation is still unknown, especially related to secreted frizzled-related protein 1 (SFRP-1), an osteoblast inhibitor. This study examines the correlation between TNF-α and SFRP-1, with a bone turn over marker (CTX and P1NP). This is a cross-sectional study with 38 subjects of premenopausal female patients with RA. This study found that 60.6% of the patients were in remission or low disease activity. The median of TNF-α was 10.6 pg/mL, mean of SFRP-1 was 9.29 ng/mL, mean of CTX was 2.74 ng/mL, and the median of P1NP was 34.04 pg/ml. There is positive correlation between TNF-α and P1NP (r = 0.363, p = 0.026), also between SFRP-1 and P1NP (r = 0.341; p = 0.036). A low level of TNF-𝛼, high level of SFRP-1, high level of CTX, and low level of P1NP in this study indicate a high bone turn over process, with dominant resorption activity in premenopausal female patients with RA.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Scatter plot of correlation between TNF-α and P1NP (a); scatter plot of correlation between SFRP-1 and P1NP (b).
See this image and copyright information in PMC

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