Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Mar 1:2020:9149762.
doi: 10.1155/2020/9149762. eCollection 2020.

Role of Secreted Frizzled-Related Protein 1 and Tumor Necrosis Factor- α (TNF- α) in Bone Loss of Patients with Rheumatoid Arthritis

Andi Raga Ginting  1 , Rudy Hidayat  1 , Sumariyono Sumariyono  1 , Sukamto Koesnoe  2
Affiliations

Role of Secreted Frizzled-Related Protein 1 and Tumor Necrosis Factor- α (TNF- α) in Bone Loss of Patients with Rheumatoid Arthritis

Andi Raga Ginting et al. Int J Rheumatol. .

Abstract

Bone loss is one of the emerging extra-articular manifestations of rheumatoid arthritis. TNF-α is the main inflammatory cytokine that can directly increase bone resorption. However, its role in bone formation is still unknown, especially related to secreted frizzled-related protein 1 (SFRP-1), an osteoblast inhibitor. This study examines the correlation between TNF-α and SFRP-1, with a bone turn over marker (CTX and P1NP). This is a cross-sectional study with 38 subjects of premenopausal female patients with RA. This study found that 60.6% of the patients were in remission or low disease activity. The median of TNF-α was 10.6 pg/mL, mean of SFRP-1 was 9.29 ng/mL, mean of CTX was 2.74 ng/mL, and the median of P1NP was 34.04 pg/ml. There is positive correlation between TNF-α and P1NP (r = 0.363, p = 0.026), also between SFRP-1 and P1NP (r = 0.341; p = 0.036). A low level of TNF-𝛼, high level of SFRP-1, high level of CTX, and low level of P1NP in this study indicate a high bone turn over process, with dominant resorption activity in premenopausal female patients with RA.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Scatter plot of correlation between TNF-α and P1NP (a); scatter plot of correlation between SFRP-1 and P1NP (b).
See this image and copyright information in PMC

References

    1. Gravallese E. M., Monach P. A. Pathogenesis and pathology of rheumatoid arthritis. In: Hochberg M. C., Gravallese E. M., Silman A. J., Smolen J. S., Weinblatt M. E., Weisman M. H., editors. Rheumatology. 7th. London: Elsevier; 2018. pp. 811–831.
    1. Darmawan J., Muirden K. D., Valkenburg H. A., Wigley R. D. The epidemiology of rheumatoid arthritis in Indonesia. British Journal of Rheumatology. 1993;32(7):537–540. doi: 10.1093/rheumatology/32.7.537. - DOI - PubMed
    1. Indonesia, PR. Diagnosis dan pengelolaan artritis reumatoid. Perhimpunan Reumatologi Indonesia; 2014.
    1. Karmakar S., Kay J., Gravallese E. M. Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention. Rheumatic Diseases Clinics of North America. 2010;36(2):385–404. doi: 10.1016/j.rdc.2010.03.003. - DOI - PMC - PubMed
    1. Shim J., Stavre Z., Gravallese E. M. Bone loss in rheumatoid arthritis: basic mechanisms and clinical implications. Calcified Tissue International. 2018;102(5):533–546. doi: 10.1007/s00223-017-0373-1. - DOI - PubMed