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. 2020 Apr;12(4):143-152.
doi: 10.3892/br.2020.1276. Epub 2020 Feb 11.

Types of acute phase reactants and their importance in vaccination

Rafaat H Khalil  1 , Nabil Al-Humadi  2
Affiliations

Types of acute phase reactants and their importance in vaccination

Rafaat H Khalil et al. Biomed Rep. 2020 Apr.

Abstract

Vaccines are considered to be one of the most cost-effective life-saving interventions in human history. The body's inflammatory response to vaccines has both desired effects (immune response), undesired effects [(acute phase reactions (APRs)] and trade-offs. Trade-offs are more potent immune responses which may be potentially difficult to separate from potent acute phase reactions. Thus, studying acute phase proteins (APPs) during vaccination may aid our understanding of APRs and homeostatic changes which can result from inflammatory responses. Depending on the severity of the response in humans, these reactions can be classified as major, moderate or minor. In this review, types of APPs and their importance in vaccination will be discussed.

Keywords: acute phase reactants; c-reactive proteins; inflammation; vaccine.

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