. 2020 Mar 20;22(1):54.

doi: 10.1186/s13075-020-2143-0.

A consensus-based framework for conducting and reporting osteoarthritis phenotype research

W E van Spil¹, S M A Bierma-Zeinstra^{2

3}, L A Deveza⁴, N K Arden^{5

6}, A-C Bay-Jensen⁷, V Byers Kraus⁸, L Carlesso⁹, R Christensen^{10

11}, M Van Der Esch¹², P Kent^{13

14}, J Knoop¹⁵, C Ladel¹⁶, C B Little¹⁷, R F Loeser¹⁸, E Losina¹⁹, K Mills²⁰, A Mobasheri²¹, A E Nelson¹⁸, T Neogi²², G M Peat^{23

24}, A-C Rat²⁵, M Steultjens²⁶, M J Thomas^{23

24}, A M Valdes²⁷, D J Hunter⁴

Affiliations

¹ Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands. w.e.vanspil@umcutrecht.nl.
² Department of General Practice, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
³ Department of Orthopedic Surgery, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
⁴ Department of Rheumatology, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia.
⁵ University of Oxford, Oxford, UK.
⁶ University of Sydney, Sydney, Australia.
⁷ Rheumatology, Nordic Bioscience, Herlev, Denmark.
⁸ School of Medicine, Duke University, Durham, USA.
⁹ Université de Montréal, Montréal, Canada.
¹⁰ Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Frederiksberg, Denmark.
¹¹ Research Unit of Rheumatology, Department of Clinical Research, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
¹² Reade, Center of Rehabilitation and Rheumatology, Amsterdam, The Netherlands.
¹³ Curtin University, Bentley, Australia.
¹⁴ University of Southern Denmark, Odense, Denmark.
¹⁵ Department of Health Sciences, VU Amsterdam, Amsterdam, The Netherlands.
¹⁶ Merck KGaA, Darmstadt, Germany.
¹⁷ Raymond Purves Labs, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia.
¹⁸ Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.
¹⁹ Brigham and Women's Hospital, Boston, USA.
²⁰ Department of Health Professions, Macquarie University, Sydney, Australia.
²¹ Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
²² School of Medicine, Boston University, Boston, USA.
²³ Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, Staffordshire, UK.
²⁴ Haywood Academic Rheumatology Centre, Midlands Partnership NHS Foundation Trust, Haywood Hospital, Staffordshire, UK.
²⁵ Université de Lorraine, EA 4360, Nancy, France.
²⁶ School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.
²⁷ School of Medicine, University of Nottingham, Nottingham, UK.

PMID: 32192519
PMCID: PMC7083005
DOI: 10.1186/s13075-020-2143-0

A consensus-based framework for conducting and reporting osteoarthritis phenotype research

W E van Spil et al. Arthritis Res Ther. 2020.

. 2020 Mar 20;22(1):54.

doi: 10.1186/s13075-020-2143-0.

Authors

Affiliations

¹ Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands. w.e.vanspil@umcutrecht.nl.
² Department of General Practice, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
³ Department of Orthopedic Surgery, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
⁴ Department of Rheumatology, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia.
⁵ University of Oxford, Oxford, UK.
⁶ University of Sydney, Sydney, Australia.
⁷ Rheumatology, Nordic Bioscience, Herlev, Denmark.
⁸ School of Medicine, Duke University, Durham, USA.
⁹ Université de Montréal, Montréal, Canada.
¹⁰ Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Frederiksberg, Denmark.
¹¹ Research Unit of Rheumatology, Department of Clinical Research, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
¹² Reade, Center of Rehabilitation and Rheumatology, Amsterdam, The Netherlands.
¹³ Curtin University, Bentley, Australia.
¹⁴ University of Southern Denmark, Odense, Denmark.
¹⁵ Department of Health Sciences, VU Amsterdam, Amsterdam, The Netherlands.
¹⁶ Merck KGaA, Darmstadt, Germany.
¹⁷ Raymond Purves Labs, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia.
¹⁸ Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.
¹⁹ Brigham and Women's Hospital, Boston, USA.
²⁰ Department of Health Professions, Macquarie University, Sydney, Australia.
²¹ Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
²² School of Medicine, Boston University, Boston, USA.
²³ Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, Staffordshire, UK.
²⁴ Haywood Academic Rheumatology Centre, Midlands Partnership NHS Foundation Trust, Haywood Hospital, Staffordshire, UK.
²⁵ Université de Lorraine, EA 4360, Nancy, France.
²⁶ School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.
²⁷ School of Medicine, University of Nottingham, Nottingham, UK.

PMID: 32192519
PMCID: PMC7083005
DOI: 10.1186/s13075-020-2143-0

Abstract

Background: The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research design and different approaches to clinical management. Although seemingly plausible, a wide range of views exist on how best to operationalize this concept. The current project aimed to provide consensus-based definitions and recommendations that together create a framework for conducting and reporting OA phenotype research.

Methods: A panel of 25 members with expertise in OA phenotype research was composed. First, panel members participated in an online Delphi exercise to provide a number of basic definitions and statements relating to OA phenotypes and OA phenotype research. Second, panel members provided input on a set of recommendations for reporting on OA phenotype studies.

Results: Four Delphi rounds were required to achieve sufficient agreement on 11 definitions and statements. OA phenotypes were defined as subtypes of OA that share distinct underlying pathobiological and pain mechanisms and their structural and functional consequences. Reporting recommendations pertaining to the study characteristics, study population, data collection, statistical analysis, and appraisal of OA phenotype studies were provided.

Conclusions: This study provides a number of consensus-based definitions and recommendations relating to OA phenotypes. The resulting framework is intended to facilitate research on OA phenotypes and increase combined efforts to develop effective OA phenotype classification. Success in this endeavor will hopefully translate into more effective, differentiated OA management that will benefit a multitude of OA patients.

Keywords: Consensus (maximum 10); Framework; Osteoarthritis; Phenotypes.

PubMed Disclaimer

Conflict of interest statement

W.E. van Spil: none.

S.M.A. Bierma-Zeinstra: provides consulting advice for Infirst Healthcare.

N.K. Arden: provides consulting advice to Merck, Flexion, Freshfields Bruckhaus, Regeneron and Pfizer/Lilly.

A.-C. Bay-Jensen: employee and shareholder at Nordic Bioscience. Partner and WP lead in the IMI-APPROACH consortium.

V. Byers Kraus: none.

L. Carlesso: none.

R. Christensen: none.

L.A. Deveza: received partial reimbursement of conference registration cost from Pfizer.

M. Van Der Esch: none.

P. Kent: none.

J. Knoop: none.

C. Ladel: employee of Merck KGaA.

C.B. Little: conducts research funded by a number pharmaceutical companies through contracts negotiated with and finances controlled by the University of Sydney and/or Northern Sydney Local Health District; provides consulting advice to Galapagos Pharmaceuticas and Merck Serono.

R.F. Loeser: provides consulting advice for Unity Biotechnology and is on the Scientific Advisory Board for Reginosine. He has received research funding from Bioventis.

E. Losina: provided consulting advice for Regeneron. Receives research funding from Genentech.

K. Mills: none.

A. Mobasheri: provided consulting advice for Abbvie, Pfizer Consumer Health (PCH), Galapagos and Servier; received funding from the European Commission through the Structural and Social Funds programmes; received investigator initiated grant support from Merck KGaA.

A.E. Nelson: provides consulting advice for Glaxo Smith Kline, receives royalties from Health Press, Ltd., provided presentations for MedScape and QuantiaMD.

T. Neogi: none.

G.M. Peat: none.

A.-C. Rat: none.

M. Steultjens: none.

M.J. Thomas: none.

A.M. Valdes: none.

D.J. Hunter: provides consulting advice for Merck Serono, Tissuegene, and TLCBio.

Figures

**Fig. 1**
Schematic overview of the general concept behind a number of the statements from the Delphi exercise

See this image and copyright information in PMC

References

1. Deveza LA, Melo L, Yamato TP, Mills K, Ravi V, Hunter DJ. Knee osteoarthritis phenotypes and their relevance for outcomes: a systematic review. Osteoarthr Cartil. 2017;25(12):1926–1941. doi: 10.1016/j.joca.2017.08.009. - DOI - PubMed
1. Deveza LA, Loeser RF. Is osteoarthritis one disease or a collection of many? Rheumatology. 2018;57(suppl_4):iv34–iv42. doi: 10.1093/rheumatology/kex417. - DOI - PMC - PubMed
1. Kent P, Keating JL, Leboeuf-Yde C. Research methods for subgrouping low back pain. BMC Med Res Methodol. 2010;10:62. doi: 10.1186/1471-2288-10-62. - DOI - PMC - PubMed
1. Dell’Isola A, Allan R, Smith SL, Marreiros SS, Steultjens M. Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature. BMC Musculoskelet Disord. 2016;17(1):425. doi: 10.1186/s12891-016-1286-2. - DOI - PMC - PubMed
1. Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012;18(5):716–725. doi: 10.1038/nm.2678. - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

A consensus-based framework for conducting and reporting osteoarthritis phenotype research

Affiliations

A consensus-based framework for conducting and reporting osteoarthritis phenotype research

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources