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. 2020 Jun;139(6):1109-1113.
doi: 10.1007/s00401-020-02142-w. Epub 2020 Mar 19.

Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation

David Castel  1   2 , Thomas Kergrohen  3   4 , Arnault Tauziède-Espariat  5   6 , Alan Mackay  7 , Samia Ghermaoui  3 , Emmanuèle Lechapt  5   6 , Stefan M Pfister  8   9   10 , Christof M Kramm  11 , Nathalie Boddaert  12 , Thomas Blauwblomme  13 , Stéphanie Puget  13 , Kévin Beccaria  3   13 , Chris Jones  7 , David T W Jones  8   14 , Pascale Varlet  5   6 , Jacques Grill  3   4 , Marie-Anne Debily  15   16
Affiliations

Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation

David Castel et al. Acta Neuropathol. 2020 Jun.
No abstract available

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References

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    1. Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N et al (2015) Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. Acta Neuropathol 130:815–827. https://doi.org/10.1007/s00401-015-1478-0 - DOI - PubMed - PMC
    1. Castel D, Philippe C, Kergrohen T, Sill M, Merlevede J, Barret E et al (2018) Transcriptomic and epigenetic profiling of ‘diffuse midline gliomas, H3 K27M-mutant’ discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location. Acta Neuropathol Commun 6:117. https://doi.org/10.1186/s40478-018-0614-1 - DOI - PubMed - PMC
    1. Hübner J-M, Müller T, Papageorgiou DN, Mauermann M, Krijgsveld J, Russell RB et al (2019) EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma. Neurooncology. https://doi.org/10.1093/neuonc/noz058 - DOI
    1. Jain SU, Do TJ, Lund PJ, Rashoff AQ, Diehl KL, Cieslik M et al (2019) PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nat Commun 10:2146. https://doi.org/10.1038/s41467-019-09981-6 - DOI - PubMed - PMC

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