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. 2021 Jan;66(1):181-189.
doi: 10.1007/s10620-020-06213-6. Epub 2020 Mar 19.

Sleep Characteristics and Rest-Activity Rhythms Are Associated with Gastrointestinal Symptoms Among Adults with Inflammatory Bowel Disease

Samantha Conley  1 , Sangchoon Jeon  2 , Vanessa Lehner  2 , Deborah D Proctor  2 , Nancy S Redeker  2
Affiliations

Sleep Characteristics and Rest-Activity Rhythms Are Associated with Gastrointestinal Symptoms Among Adults with Inflammatory Bowel Disease

Samantha Conley et al. Dig Dis Sci. 2021 Jan.

Abstract

Background: Sleep disturbance is common in inflammatory bowel disease (IBD) and is associated with poorer quality of life and increased disease activity; however, sleep is a multidimensional process, and little is known about specific sleep characteristics and rest-activity rhythms (RARs) in this population.

Aims: The purposes were to (1) describe sleep characteristics and RARs; (2) compare sleep characteristics and RARs and GI symptoms by disease activity; and (3) describe associations between sleep characteristics, RARs, and GI symptoms among adults with IBD.

Methods: We conducted a cross-sectional study of adults with IBD. We measured sleep characteristics and RARs (continuous wrist actigraphy); GI symptoms (PROMIS-GI); and disease activity (physicians' global assessment). We conducted cosinor and nonparametric analyses to compute RAR variables and bivariate analyses to address the aims.

Results: The sample included 37 participants [age M = 38 years (SD = 13.8) and 21 (56.8%) female], of whom 23 (60.6%) were in remission. Sleep efficiency [M = 82.91% (SD 5.35)] and wake after sleep onset (WASO) [M = 42.26 min (SD 18.57)] were not associated with disease activity. Inter-daily stability of the RAR was associated with heartburn/reflux (r = - .491, p = .005) and gas/bloating (r = - .469, p = .008). Intra-daily variability of the RAR was associated with heartburn/reflux (r = .421, p = .018).

Conclusions: People with IBD may have disrupted RARs, which are associated with GI symptoms. Research is needed to improve understanding of these associations and to develop interventions to improve these characteristics in adults with IBD.

Keywords: Actigraphy; Circadian rhythms; Inflammatory bowel diseases; Rest–activity; Sleep.

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References

    1. Shivashankar R, Tremaine WJ, Harmsen WS, Loftus EV. Incidence and prevalence of crohn’s disease and ulcerative colitis in Olmsted County, Minnesota from 1970 through 2010. Clin Gastroenterol Hepatol. 2017;15:857–863. - PMC - PubMed
    1. Conley S, Proctor DD, Jeon S, Sandler RS, Redeker NS. Symptoms clusters in adults with inflammatory bowel disease. Research in Nursing and Health. 2017;40:424–34. - PMC - PubMed
    1. Borbely AA, Daan S, Wirz-Justice A, Deboer T. The two-process model of sleep regulation: A reappraisal. J Sleep Res. 2016;25:131–143. doi:10.1111/jsr.12371. - DOI - PubMed
    1. Gingold-Belfer R, Peled N, Levy S, et al. Impaired sleep quality in Crohn’s disease depends on disease activity. Dig Dis Sci. 2013. doi:10.1007/s10620-013-2890-8. - DOI - PubMed
    1. Ali T, Madhoun MF, Orr WC, Rubin DT. Assessment of the relationship between quality of sleep and disease activity in inflammatory bowel disease patients. Inflamm Bowel Dis. 2013;19:2440–2443. doi:10.1097/MIB.0b013e3182a0ea54. - DOI - PubMed

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