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. 2020 Mar;19(3):2522-2526.
doi: 10.3892/ol.2020.11329. Epub 2020 Jan 22.

Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients

Rosa Porzio  1 , Claudia Cordini  2 , Anna Maria Rodolfi  2 , Francesca Brigati  2 , Alessandro Ubiali  3 , Manuela Proietto  1 , Camilla Di Nunzio  1 , Luigi Cavanna  1
Affiliations

Triple negative endometrial cancer: Incidence and prognosis in a monoinstitutional series of 220 patients

Rosa Porzio et al. Oncol Lett. 2020 Mar.

Abstract

Endometrial cancer (EC) represents the most frequently occuring gynecological tumor worldwide. The aim of the present study was to estimate the prognostic value of triple negative phenotype (TNP) in EC, and any associations with to pathological and clinical characteristics. The present study includes 220 cases of patients with EC who underwent to surgery at the Guglielmo da Saliceto Hospital of Piacenza (Italy) and the expressions of estrogen receptor (ER), progesterone receptor (PR) and oncoprotein c-erbB-2 (HER2) expression were examined. Pearson's Chi-square and Fisher's exact test were used to evaluate the association of TNP cases with variables associated with a worse prognosis. Progression-free survival (PFS) and overall survival (OS) were analyzed with Kaplan-Meier curves. A total of 26 patients (12%) had a TNP, and these cases had a higher percentage of high-risk histology, an advanced stage of disease at the time of diagnosis, with shorter PFS and OS when compared to non-TNP. The present study confirmed that TNP represents prognostic significance in EC.

Keywords: endometrial cancer; gynecologic cancer; triple negative endometrial cancer.

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Figures

Figure 1.
Figure 1.
Kaplan-Meier plots for DFS and OS in TNECs and non-TNECs. Dots, censored cases (mortality from other cause or quit follow-up). DFS, disease-free survival; OS, overall survival; TNEC, triple negative endometrial cancer; non-TNEC, non-triple negative endometrial cancer.
See this image and copyright information in PMC

References

    1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009;59:225–249. doi: 10.3322/caac.20006. - DOI - PubMed
    1. Colombo N, Preti E, Landoni F, Carinelli S, Colombo A, Marini C, Sessa C, ESMO Guidelines Working Group Endometrial cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24(Suppl 6):vi33–vi38. doi: 10.1093/annonc/mdt353. - DOI - PubMed
    1. Kounelis S, Kapranos N, Kouri E, Coppola D, Papadaki H, Jones MW. Immunohistochemical profile of endometrial adenocarcinoma: A study of 61 cases and review of the literature. Mod Pathol. 2000;13:379–388. doi: 10.1038/modpathol.3880062. - DOI - PubMed
    1. Talhouk A, McConechy MK, Leung S, Li-Chang HH, Kwon JS, Melnyk N, Yang W, Senz J, Boyd N, Karnezis AN, et al. A clinically applicable molecular-based classification for endometrial cancers. Br J Cancer. 2015;113:299–310. doi: 10.1038/bjc.2015.190. - DOI - PMC - PubMed
    1. Wu T, Wang Y, Jiang R, Lu X, Tian J. A pathways-based prediction model for classifying breast cancer subtypes. Oncotarget. 2017;8:58809–58822. - PMC - PubMed