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. 2020 Apr;35(3):163-166.
doi: 10.1089/cbr.2019.3301. Epub 2020 Mar 20.

The Current Status of the Production and Supply of Gallium-68

Krishan Kumar  1
Affiliations

The Current Status of the Production and Supply of Gallium-68

Krishan Kumar. Cancer Biother Radiopharm. 2020 Apr.

Abstract

Gallium-68 (68Ga) is an important radionuclide due to its successful use in the clinic. Currently, 68Ga is produced and supplied by using germanium-68/Gallium-68 (68Ge/68Ga) generator systems in the preclinical and clinical environments. Until recently, the supply of 68Ge/68Ga generators, specifically the good manufacturing practices (GMP) grade, had a long lead time (up to 18 months). This led researchers to investigate the cyclotron production of 68Ga by using solid and liquid targets. This report summarizes an overview of the chemistry, coordination chemistry, and radiochemistry of Ga and the current status of manufacturing and supply of 68Ga radionuclide.

Keywords: 68Ga; 68Ge/68Ga generators; cyclotron produced 68Ga; liquid targets; production and supply; solid targets.

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