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. 2020 Mar;24(5):2616-2624.
doi: 10.26355/eurrev_202003_20530.

Long non-coding RNA MIR4435-2HG recruits miR-802 from FLOT2 to promote melanoma progression

D-M Ma  1 , D Sun, J Wang, D-H Jin, Y Li, Y-E Han
Affiliations
Free article

Long non-coding RNA MIR4435-2HG recruits miR-802 from FLOT2 to promote melanoma progression

D-M Ma et al. Eur Rev Med Pharmacol Sci. 2020 Mar.
Free article

Abstract

Objective: The regulatory mechanism of lncRNA MIR4435-2HG has been extensively investigated in human cancers other than melanoma. This study aims to elucidate the role of lncRNA MIR4435-2HG in melanoma.

Material and methods: The mRNA expression was detected by RT-qPCR. MTT assay, Transwell assay and Dual-Luciferase reporter assay were used to investigate the regulatory mechanism of lncRNA MIR4435-2HG.

Results: Upregulation of lncRNA MIR4435-2HG was identified in melanoma and promoted melanoma cell proliferation, migration and invasion. In addition, lncRNA MIR4435-2HG serves as the ceRNA of miR-802. MiR-802 inhibited melanoma progression by downregulating lncRNA MIR4435-2HG. Besides, miR-802 directly targets FLOT2. And knockdown of FLOT2 restrained the progression of melanoma by downregulating lncRNA MIR4435-2HG and upregulating miR-802.

Conclusions: LncRNA MIR4435-2HG promotes cell proliferation, migration and invasion in melanoma by sponging miR-802 and upregulating FLOT2.

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