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Review
. 2020 Aug 1;108(8):1617-1633.
doi: 10.1002/jbm.a.36930. Epub 2020 Mar 31.

Biomaterials and biocompatibility: An historical overview

Elia Marin  1   2 , Francesco Boschetto  1 , Giuseppe Pezzotti  1   3   4   5
Affiliations
Review

Biomaterials and biocompatibility: An historical overview

Elia Marin et al. J Biomed Mater Res A. .

Abstract

This review focuses on the characteristics and applications of biomaterials through the ages, ranging from the prehistoric times to the beginning of the era of modern medicine, which has been arbitrarily set to the middle of the 19th century, when aseptic procedures, antiseptic substances and modern anesthetics were developed. After a brief discussion on the definition of "biomaterial" from an historical point of view and a short introduction on the general history of surgery and dentistry, each material or class of materials will be presented with references listed in chronological order and, where possible, with their real, scientifically demonstrated effects on biological tissues. Particular attention has been given to references that are nowadays considered spurious or affected by translation errors or other kinds of biases.

Keywords: biocompatibility; biomaterials; history; materials; overview; review.

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References

REFERENCES

    1. Abraham, H. (1918). Asphalts and allied substances: Their occurrence, modes of production, uses in the arts and methods of testing. New York, NY: D. van Nostrand.
    1. Afnan, S. M. (2015). Avicenna: His life and works. Abingdon-on-Thames, England: Routledge.
    1. Agrawal, A., & Garg, L. N. (2011). Split calvarial bone graft for the reconstruction of skull defects. Journal of Surgical Technique and Case Report, 3, 13.
    1. Allison, M. J., & Pezzia, A. (1976). Treatment of head wounds in Pre-Columbian and Colonial Peru. Medical College of Virginia Quarterly, 12, 74-79.
    1. Alt, K. W., Jeunesse, C., Buitrago-Tellez, C. H., Wachter, R., Boes, E., & Pichler, S. L. (1997). Evidence for stone age cranial surgery. Nature, 387, 360.

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