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Comment
. 2020 May;10(5):OF9.
doi: 10.1158/2159-8290.CD-RW2020-042. Epub 2020 Mar 20.

Non-Stem Cells Seed Colorectal Cancer Metastases and Gain Stem Traits

No authors listed
Comment

Non-Stem Cells Seed Colorectal Cancer Metastases and Gain Stem Traits

No authors listed. Cancer Discov. 2020 May.

Abstract

LGR5- cells seed colorectal cancer metastases and produce stemlike LGR5+ outgrowth-promoting cells.

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  • Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer.
    Fumagalli A, Oost KC, Kester L, Morgner J, Bornes L, Bruens L, Spaargaren L, Azkanaz M, Schelfhorst T, Beerling E, Heinz MC, Postrach D, Seinstra D, Sieuwerts AM, Martens JWM, van der Elst S, van Baalen M, Bhowmick D, Vrisekoop N, Ellenbroek SIJ, Suijkerbuijk SJE, Snippert HJ, van Rheenen J. Fumagalli A, et al. Cell Stem Cell. 2020 Apr 2;26(4):569-578.e7. doi: 10.1016/j.stem.2020.02.008. Epub 2020 Mar 12. Cell Stem Cell. 2020. PMID: 32169167 Free PMC article.

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