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. 2020 Mar 20;11(2):e00398-20.
doi: 10.1128/mBio.00398-20.

Hiding in Plain Sight: an Approach to Treating Patients with Severe COVID-19 Infection

David S Fedson  1 , Steven M Opal  2 , Ole Martin Rordam  3
Affiliations

Hiding in Plain Sight: an Approach to Treating Patients with Severe COVID-19 Infection

David S Fedson et al. mBio. .

Abstract

Patients with COVID-19 infection are at risk of acute respiratory disease syndrome (ARDS) and death. The tissue receptor for COVID-19 is ACE2, and higher levels of ACE2 can protect against ARDS. Angiotensin receptor blockers and statins upregulate ACE2. Clinical trials are needed to determine whether this drug combination might be used to treat patients with severe COVID-19 infection.

Keywords: COVID-19; endothelial dysfunction; generic drugs; host response treatment.

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