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. 2020 Apr;118(2):139-142.
doi: 10.5546/aap.2020.eng.139.

Predictive role of neutrophil to lymphocyte ratio and mean platelet volume in Henoch-Schönlein purpura related gastrointestinal and renal involvement

[Article in English, Spanish]
Halil I Yakut  1 , Tuba Kurt  2 , Nermin Uncu  2 , F Semsa Cayci  3 , Banu Celikel Acar  4
Affiliations
Free article

Predictive role of neutrophil to lymphocyte ratio and mean platelet volume in Henoch-Schönlein purpura related gastrointestinal and renal involvement

[Article in English, Spanish]
Halil I Yakut et al. Arch Argent Pediatr. 2020 Apr.
Free article

Abstract
in English, Spanish

Background: Henoch-Schönlein purpura (HSP) is a systemic small-vessel vasculitis that occurs mainly in children. The aim was to evaluate the blood neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) in patients with HSP and to investigate the relationship with gastrointestinal and renal involvement.

Methods: Children with HSP and healthy individuals as controls were included. Hemoglobin level, white blood cell count, platelet count, NLR, MPV erythrocyte sedimentation rate and C-reactive protein were evaluated.

Results: There were 71 HSP children and 74 controls. NLR was significantly higher in HSP patients with gastrointestinal bleeding than without gastrointestinal bleeding (p < 0,001). The optimal cutoff value of NLR for predicting gastrointestinal bleeding was 2.05, with 93 % sensitivity and 62 % specificity. MPV was significantly higher in HSP patients with renal involvement than without renal involvement (p = 0,027).

Conclusions: Blood NLR and MPV may be useful markers to identify gastrointestinal and renal involvement in HSP patients.

Antecedentes: La púrpura de Henoch-Schönlein (PHS) es una vasculitis sistémica de vasos pequeños. El objetivo fue evaluar elíndicedeneutrófilos/linfocitos (INL) ensangreyelvolumen plaquetario medio (VPM) en la PHS e investigar la relación con el compromiso renal y gastrointestinal. Métodos: Se incluyeron niños con PHS y controles sanos. Se evaluaron concentración de hemoglobina, recuento de leucocitos, recuento de trombocitos, INL, VPM, velocidad de sedimentación globular y proteína C-reactiva. Resultados: El INL fue significativamente mayor en los pacientes con PHS con hemorragia gastrointestinal (p < 0,001). El valor ideal de corte del INL para predecir la hemorragia gastrointestinal fue 2,05, con 93 % de sensibilidad y 62 % de especificidad. El VPM fue significativamente mayor en los pacientes con PHS con compromiso renal (p = 0,027). Conclusiones: El INL en sangre y el VPM podrían ser útiles para identificar el compromiso renal y gastrointestinal en la PHS.

Keywords: Henoch-Schönlein purpura; blood neutrophil-to-lymphocyte ratio; gastrointestinal hemorrhage; kidney disease; mean platelet volume.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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