Viral dynamics in mild and severe cases of COVID-19

doi:10.1016/S1473-3099(20)30232-2

. 2020 Jun;20(6):656-657.

doi: 10.1016/S1473-3099(20)30232-2. Epub 2020 Mar 19.

Viral dynamics in mild and severe cases of COVID-19

Yang Liu¹, Li-Meng Yan², Lagen Wan², Tian-Xin Xiang³, Aiping Le⁴, Jia-Ming Liu⁵, Malik Peiris², Leo L M Poon⁶, Wei Zhang⁷

Affiliations

¹ Department of Clinical Microbiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
² School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
³ Department of Infectious Disease, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
⁴ Department of Blood Transfusion, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
⁵ Department of Orthopedic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
⁶ School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: llmpoon@hku.hk.
⁷ Department of Respiration, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China. Electronic address: zhangweiliuxin@163.com.

PMID: 32199493
PMCID: PMC7158902
DOI: 10.1016/S1473-3099(20)30232-2

Viral dynamics in mild and severe cases of COVID-19

Yang Liu et al. Lancet Infect Dis. 2020 Jun.

. 2020 Jun;20(6):656-657.

doi: 10.1016/S1473-3099(20)30232-2. Epub 2020 Mar 19.

Authors

Yang Liu¹, Li-Meng Yan², Lagen Wan², Tian-Xin Xiang³, Aiping Le⁴, Jia-Ming Liu⁵, Malik Peiris², Leo L M Poon⁶, Wei Zhang⁷

Affiliations

¹ Department of Clinical Microbiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
² School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
³ Department of Infectious Disease, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
⁴ Department of Blood Transfusion, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
⁵ Department of Orthopedic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
⁶ School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: llmpoon@hku.hk.
⁷ Department of Respiration, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China. Electronic address: zhangweiliuxin@163.com.

PMID: 32199493
PMCID: PMC7158902
DOI: 10.1016/S1473-3099(20)30232-2

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Figures

**Figure**
Viral dynamics in patients with mild and severe COVID-19 (A) DCT values (Ct_sample-Ct_ref) from patients with mild and severe COVID-19 at different stages of disease onset. Median, quartile 1, and quartile 3 are shown. (B) DCT values of serial samples from patients with mild and severe COVID-19. COVID-19=coronavirus disease 2019. *p<0·005.

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References

1. Pan Y, Zhang D, Yang P, Poon LLM, Wang Q. Viral load of SARS-CoV-2 in clinical samples. Lancet Infect Dis. 2020 doi: 10.1016/S1473-3099(20)30113-4. published online Feb 24. - DOI - PMC - PubMed
1. Zou L, Ruan F, Huang M. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020 doi: 10.1056/NEJMc2001737. published online Jan 30. - DOI - PMC - PubMed
1. Guan WJ, Ni ZY, Hu Y. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020 doi: 10.1056/NEJMoa2002032. published online Feb 28. - DOI - PMC - PubMed
1. Yang X, Yu Y, Xu J. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020 doi: 10.1016/S2213-2600(20)30079-5. published online Feb 24. - DOI - PMC - PubMed
1. WHO Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases. 2020. https://www.who.int/publications-detail/laboratory-testing-for-2019-nove...

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[1] Pan Y, Zhang D, Yang P, Poon LLM, Wang Q. Viral load of SARS-CoV-2 in clinical samples. Lancet Infect Dis. 2020 doi: 10.1016/S1473-3099(20)30113-4. published online Feb 24. - DOI - PMC - PubMed

[2] Pan Y, Zhang D, Yang P, Poon LLM, Wang Q. Viral load of SARS-CoV-2 in clinical samples. Lancet Infect Dis. 2020 doi: 10.1016/S1473-3099(20)30113-4. published online Feb 24. - DOI - PMC - PubMed

[3] Zou L, Ruan F, Huang M. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020 doi: 10.1056/NEJMc2001737. published online Jan 30. - DOI - PMC - PubMed

[4] Zou L, Ruan F, Huang M. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020 doi: 10.1056/NEJMc2001737. published online Jan 30. - DOI - PMC - PubMed

[5] Guan WJ, Ni ZY, Hu Y. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020 doi: 10.1056/NEJMoa2002032. published online Feb 28. - DOI - PMC - PubMed

[6] Guan WJ, Ni ZY, Hu Y. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020 doi: 10.1056/NEJMoa2002032. published online Feb 28. - DOI - PMC - PubMed

[7] Yang X, Yu Y, Xu J. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020 doi: 10.1016/S2213-2600(20)30079-5. published online Feb 24. - DOI - PMC - PubMed

[8] Yang X, Yu Y, Xu J. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020 doi: 10.1016/S2213-2600(20)30079-5. published online Feb 24. - DOI - PMC - PubMed

[9] WHO Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases. 2020. https://www.who.int/publications-detail/laboratory-testing-for-2019-nove...

[10] WHO Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases. 2020. https://www.who.int/publications-detail/laboratory-testing-for-2019-nove...

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Viral dynamics in mild and severe cases of COVID-19

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Viral dynamics in mild and severe cases of COVID-19

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