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. 2020 Jun:143:104559.
doi: 10.1016/j.fitote.2020.104559. Epub 2020 Mar 19.

Oxylipin vanillyl acetals from Solanum lyratum

Shuang-Shuang Li  1 , Qing-Bo Liu  1 , Yang-Yang Zhang  1 , Shao-Chun Shi  1 , Rui Guo  1 , Guo-Dong Yao  1 , Bin Lin  2 , Xiao-Xiao Huang  3 , Shao-Jiang Song  4
Affiliations

Oxylipin vanillyl acetals from Solanum lyratum

Shuang-Shuang Li et al. Fitoterapia. 2020 Jun.

Abstract

Four undescribed oxylipin vanillyl acetals with four stereogenic carbons were isolated from the herbs of Solanum lyratum. A comprehensive set of spectroscopic methods were used to elucidate the structures and relative configurations of 1-4. The absolute configurations of the naturally occurring compounds are assigned as 7S, 9'S, 10'S, 11'R at the site of six-membered cyclic acetal attachment by electronic circular dichroism (ECD) calculations and the modified Mosher's method. Compounds 1 and 3 displayed moderate selective inhibition against Hep3B and HepG2 cells, respectively. Further Annexin V-FITC/PI staining assay revealed that 1 and 3 might have inhibitory effects on hepatoma cells through induction of apoptosis.

Keywords: Apoptosis; Inhibitory effect; Oxylipin vanillyl acetals; Solanum lyratum.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that there are no conflicts of interest.

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