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Observational Study
. 2020 Aug;35(8):1154-1163.
doi: 10.1007/s00380-020-01578-0. Epub 2020 Mar 21.

Decreased mean perfusion pressure as an independent predictor of acute kidney injury after cardiac surgery

Raymond Hu  1 , Yasmean Kalam  2 , Jeremy Broad  2 , Tim Ho  2 , Frank Parker  2 , Matthew Lee  2 , Rinaldo Bellomo  3
Affiliations
Observational Study

Decreased mean perfusion pressure as an independent predictor of acute kidney injury after cardiac surgery

Raymond Hu et al. Heart Vessels. 2020 Aug.

Abstract

Acute kidney injury after cardiac surgery (AKICS) is common. Previous studies examining the role that mean arterial pressure (MAP) during cardiopulmonary bypass (CPB) may have on AKICS have not taken into account how baseline central venous pressure (CVP) and mean perfusion pressure (MPP) (i.e. MAP - CVP) can influence its evolution. To assess whether the change in MPP to the kidneys (i.e. delta MPP or DMPP) during CPB compared to baseline is an independent predictor of AKICS. After ethical approval, a retrospective observational study was performed on all patients undergoing CPB between October 2013 and June 2015 at a university-affiliated hospital. Known risk factors for the development of AKICS were recorded, as were the MPP values at baseline and during CPB. From this, statistical modelling was performed to identify predictors of postoperative AKICS. 664 patients were identified. Analysis was performed on 513 patients after exclusion. On logistic regression, significant and independent predictors of AKICS included: d20DMPP (cumulative duration of MPP values during CPB that were 20% below baseline and exceeded three consecutive minutes) (P = 0.010); baseline CVP; age; pre-operative creatinine level; and left ventricular (LV) dysfunction (ejection fraction (EF) < 45%). On alternative modelling, the cumulative number of MPP values during CPB that were 10% below baseline was also independently associated with AKICS (P = 0.003). Modelling without taking into account CVP also supported this association. The duration of differences in perfusion pressure to the kidneys during CPB compared to baseline is an independent predictor of AKICS.

Keywords: Acute kidney injury; Cardiac surgery; Cardiopulmonary bypass; Central venous pressure; Mean arterial pressure; Mean perfusion pressure.

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Conflict of interest statement

No funding was received for the conduct of this study. The authors declare they have no competing commercial interests.

Figures

Fig. 1
Fig. 1
STROBE flow chart. DHCA deep hypothermic circulatory arrest, SCAP selective cerebral antegrade perfusion, CPB cardiopulmonary bypass
See this image and copyright information in PMC

References

    1. Moore EM, Bellomo R, Nichol AD. The meaning of acute kidney injury and its relevance to intensive care and anaesthesia. Anaesth Intensive Care. 2012;40:929–948. doi: 10.1177/0310057X1204000604. - DOI - PubMed
    1. Sickeler R, Phillips-Bute B, Kertai MD, Schroder J, Mathew JP, Swaminathan M, Stafford-Smith M. The risk of acute kidney injury with co-occurrence of anemia and hypotension during cardiopulmonary bypass relative to anemia alone. Ann Thorac Surg. 2014;97:865–871. doi: 10.1016/j.athoracsur.2013.09.060. - DOI - PubMed
    1. Corwin HL, Sprague SM, Delaria GA, Norusis MJ. Acute renal failure associated with cardiac operations. A case–control study. J Thorac Cardiovasc Surg. 1989;98:1107–1112. doi: 10.1016/S0022-5223(19)34326-0. - DOI - PubMed
    1. Pickering JW, James MT, Palmer SC. Acute kidney injury and prognosis after cardiopulmonary bypass: a meta-analysis of cohort studies. Am J Kidney Dis. 2015;65:283–293. doi: 10.1053/j.ajkd.2014.09.008. - DOI - PubMed
    1. Corredor C, Thomson R, Al-Subaie N. Long-term consequences of acute kidney injury after cardiac surgery: a systematic review and meta-analysis. J Cardiothorac Vasc Anesth. 2016;30:69–75. doi: 10.1053/j.jvca.2015.07.013. - DOI - PubMed

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