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. 2020 Jun;10(3):449-464.
doi: 10.1007/s13555-020-00365-z. Epub 2020 Mar 21.

Patient Education Programs in Pediatric Atopic Dermatitis: A Systematic Review of Randomized Controlled Trials and Meta-Analysis

Mutong Zhao  1 , Yuan Liang  1 , Chunping Shen  1 , Ying Wang  2 , Lin Ma  3 , Xiuhua Ma  4
Affiliations

Patient Education Programs in Pediatric Atopic Dermatitis: A Systematic Review of Randomized Controlled Trials and Meta-Analysis

Mutong Zhao et al. Dermatol Ther (Heidelb). 2020 Jun.

Abstract

Introduction: Patient education is crucial for improving disease outcomes in atopic dermatitis (AD). This review aims to summarize evidence about the effectiveness of educational programs for parents of pediatric AD patients.

Methods: PubMed and Embase (inception to Feb 2020) were searched and randomized controlled trials (RCTs) in English were included. Risk of bias was assessed using Cochrane risk of bias tools and quality of evidence was assessed by Grading of Recommendations Assessment, Development and Evaluation (GRADE). Pooled standardized mean difference (SMD) and 95% confidence intervals (CIs) were calculated for the disease severity instrument (Scoring of Atopic Dermatitis, SCORAD) and quality of life (QoL) instruments using the random-effects model.

Results: A total of 13 RCTs were included in the systematic review. The meta-analysis of SCORAD contained seven studies with a total of 1853 patients. The reduction in disease severity (SCORAD) was larger in the treatment group (SMD = - 8.22, 95% CI = - 11.29, - 5.15; P < 0.001; I2 = 78.6%). Subgroup analyses revealed that the association was modified by the frequency of sessions (P for Cochran Q < 0.01) and the duration of follow-up (P for Cochran Q < 0.01). No significant effect-modification was observed for disease severity and borderline significance was observed for session delivery (individual vs group session). The pooled effect sizes for QoL measures including Dermatitis Family Index (SMD = - 0.65, 95% CI = - 1.49, 0.18), Children's Dermatology Life Quality Index (SMD = - 1.61, 95% CI = - 3.76, 0.55; I2= 89.0%) and Infants' Dermatology Quality of Life Index (SMD = 0.30, 95% CI = - 1.04, 1.63; I2= 63.1%) were not significant.

Conclusions: Structured patient education is beneficial and should be implemented for the management of AD patients. However, an optimal delivery mode needs to be determined.

Keywords: Atopic dermatitis; Education; Meta-analysis; Parental education; Pediatric; Systematic review.

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Conflict of interest statement

Mutong Zhao, Yuan Liang, Chunping Shen, Ying Wang, Lin Ma, and Xiuhua Ma have nothing to disclose.

Figures

Fig. 1
Fig. 1
Flow diagram of study selection. SCORAD Scoring of Atopic Dermatitis, DFI Dermatitis Family Index, IDQOL Infants’ Dermatitis Quality of Life, CDLQI Children’s Dermatology Life Quality Index, RCT randomized controlled trial
Fig. 2
Fig. 2
Standardized mean difference (SMD) for Scoring of Atopic Dermatitis (SCORAD, a), Dermatitis Family Index (DFI, b), Infants’ Dermatitis Quality of Life (IDQOL, c), and Children’s Dermatology Life Quality Index (CDLQI, d) at the end of study. The dots represent point estimates of SMD while the horizontal lines represent the 95% CI for the SMD. The size of the square around each SMD is proportional to the study weight. I2 represents the degree of heterogeneity in the included studies. The pooled SMD (diamond) was calculated using a random effects model
See this image and copyright information in PMC

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