Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities

doi:10.1007/s11418-020-01395-9

. 2020 Jun;74(3):591-598.

doi: 10.1007/s11418-020-01395-9. Epub 2020 Mar 21.

Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities

Affiliations

¹ Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue, Vietnam.
² Faculty of Basic Science, Hue University of Agriculture and Forestry, Hue University, 102 Phung Hung, Hue, Vietnam.
³ Faculty of Chemistry, Hue University of Education, Hue University, 34 Le Loi, Hue, Vietnam.
⁴ Quang Tri Center of Science and Technology, Mientrung Inst. for Scientific Research, VAST, Dien Bien Phu, Dong Ha, Quang Tri, Vietnam.
⁵ Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
⁶ Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
⁷ Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan. hmorita@inm.u-toyama.ac.jp.
⁸ Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue, Vietnam. hoai77@gmail.com.

PMID: 32200514
DOI: 10.1007/s11418-020-01395-9

Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities

Duc Viet Ho et al. J Nat Med. 2020 Jun.

. 2020 Jun;74(3):591-598.

doi: 10.1007/s11418-020-01395-9. Epub 2020 Mar 21.

Authors

Affiliations

¹ Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue, Vietnam.
² Faculty of Basic Science, Hue University of Agriculture and Forestry, Hue University, 102 Phung Hung, Hue, Vietnam.
³ Faculty of Chemistry, Hue University of Education, Hue University, 34 Le Loi, Hue, Vietnam.
⁴ Quang Tri Center of Science and Technology, Mientrung Inst. for Scientific Research, VAST, Dien Bien Phu, Dong Ha, Quang Tri, Vietnam.
⁵ Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
⁶ Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
⁷ Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan. hmorita@inm.u-toyama.ac.jp.
⁸ Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue, Vietnam. hoai77@gmail.com.

PMID: 32200514
DOI: 10.1007/s11418-020-01395-9

Abstract

Three new steroidal saponins, aspiletreins A-C (1-3), together with 2H-chromen-2-one (4), and α-tocopherol (5), were isolated from whole Aspidistra letreae plants collected in Vietnam. Their structures were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR, IR, and HRESIMS, and by comparison with the reported data in the literature. Compounds 1-3 exhibited moderate cytotoxicities against the LU-1, HeLa, MDA-MB-231, HepG2, and MKN-7 human cancer cell lines, with IC₅₀ values ranging from 7.69 ± 0.40 to 20.46 ± 3.11 µM.

Keywords: Aspidistra letreae; Aspiletreins A–C; Cytotoxicity; Saponin.

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References

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[1] Molecules. 2018 Oct 08;23(10): - PubMed

[2] Molecules. 2018 Oct 08;23(10): - PubMed

[3] Phytochemistry. 2017 Dec;144:113-118 - PubMed

[4] Phytochemistry. 2017 Dec;144:113-118 - PubMed

[5] Z Naturforsch C J Biosci. 2015;70(1-2):7-13 - PubMed

[6] Z Naturforsch C J Biosci. 2015;70(1-2):7-13 - PubMed

[7] PLoS One. 2016 Mar 03;11(3):e0150595 - PubMed

[8] PLoS One. 2016 Mar 03;11(3):e0150595 - PubMed

[9] Nat Protoc. 2012 Sep;7(9):1590-607 - PubMed

[10] Nat Protoc. 2012 Sep;7(9):1590-607 - PubMed

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Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities

Affiliations

Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities

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