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Comment
. 2020 Mar 19;77(6):1155-1156.
doi: 10.1016/j.molcel.2020.02.027.

Brain Translation: A Feather Tips the Scale

Dmytro Ustianenko  1 , Melissa G McKenzie  1 , Chaolin Zhang  2
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Comment

Brain Translation: A Feather Tips the Scale

Dmytro Ustianenko et al. Mol Cell. .
Free article

Abstract

In this issue of Molecular Cell, Gonatopoulos-Pournatzis et al. (2020) report a neuron-specific microexon in eIF4G translation initiation factors that dampens synaptic protein translation. Autism-associated disruption of this exon results in increased protein production, likely through reduced coalescence with cytoplasmic ribonucleoprotein granule components, including FMRP.

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  • Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.
    Gonatopoulos-Pournatzis T, Niibori R, Salter EW, Weatheritt RJ, Tsang B, Farhangmehr S, Liang X, Braunschweig U, Roth J, Zhang S, Henderson T, Sharma E, Quesnel-Vallières M, Permanyer J, Maier S, Georgiou J, Irimia M, Sonenberg N, Forman-Kay JD, Gingras AC, Collingridge GL, Woodin MA, Cordes SP, Blencowe BJ. Gonatopoulos-Pournatzis T, et al. Mol Cell. 2020 Mar 19;77(6):1176-1192.e16. doi: 10.1016/j.molcel.2020.01.006. Epub 2020 Jan 29. Mol Cell. 2020. PMID: 31999954

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