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. 2020 Mar 19;77(6):1159-1161.
doi: 10.1016/j.molcel.2020.02.026.

ATACing DNA Methylation during Differentiation

Skirmantas Kriaucionis  1 , Robert J Klose  2
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ATACing DNA Methylation during Differentiation

Skirmantas Kriaucionis et al. Mol Cell. .
Free article

Abstract

Distal regulatory elements control gene expression during differentiation. In this issue of Molecular Cell, Barnett et al. (2020) develop a new technology, called ATAC-Me, and discover that removal of DNA methylation is not a pre-requisite for the creation of accessible chromatin at active gene regulatory elements during cellular differentiation.

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