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Comment
. 2020 Mar 19;180(6):1039-1041.
doi: 10.1016/j.cell.2020.02.053.

Repair, Removal, and Shutdown: It All Hinges on RNA Polymerase II Ubiquitylation

Kook Son  1 , Orlando D Schärer  2
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Free article
Comment

Repair, Removal, and Shutdown: It All Hinges on RNA Polymerase II Ubiquitylation

Kook Son et al. Cell. .
Free article

Abstract

Two papers, by Nakazawa and Vidaković, show how ubiquitylation of a single lysine residue in RNA polymerase II serves as a master switch to regulate transcription, RNA polymerase II degradation, and transcription-coupled nucleotide excision repair in response to DNA damage.

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  • Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
    Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y, Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T. Nakazawa Y, et al. Cell. 2020 Mar 19;180(6):1228-1244.e24. doi: 10.1016/j.cell.2020.02.010. Epub 2020 Mar 5. Cell. 2020. PMID: 32142649
  • Regulation of the RNAPII Pool Is Integral to the DNA Damage Response.
    Tufegdžić Vidaković A, Mitter R, Kelly GP, Neumann M, Harreman M, Rodríguez-Martínez M, Herlihy A, Weems JC, Boeing S, Encheva V, Gaul L, Milligan L, Tollervey D, Conaway RC, Conaway JW, Snijders AP, Stewart A, Svejstrup JQ. Tufegdžić Vidaković A, et al. Cell. 2020 Mar 19;180(6):1245-1261.e21. doi: 10.1016/j.cell.2020.02.009. Epub 2020 Mar 5. Cell. 2020. PMID: 32142654 Free PMC article.

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