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. 2020 May 15:597:113695.
doi: 10.1016/j.ab.2020.113695. Epub 2020 Mar 19.

Very long-term stability of lipid biomarkers in human serum

Vladimira Muzakova  1 , Piet K Beekhof  2 , Eugène H J M Jansen  3
Affiliations

Very long-term stability of lipid biomarkers in human serum

Vladimira Muzakova et al. Anal Biochem. .

Abstract

The assessment of the stability of biomarkers is very important for epidemiological studies. In this study, the stability of five lipid parameters (total cholesterol, triglycerides, HDL- and LDL-cholesterol and free fatty acids) has been tested in 16 human serum samples after storage at -80 °C up at time points 0, 1, 8 and 13 y. The majority of the lipid biomarkers were stable during storage conditions, except for cholesterol. The correlations between the samples were very good at time points. Therefore, long-term storage of human serum samples allows lipid biomarker determination, provided that the samples are stored at -80 °C.

Keywords: Human serum; Lipid biomarkers; Storage stability.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflicts of interest.

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