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. 2020 Mar;36(2):111-117.
doi: 10.6515/ACS.202003_36(2).20190731A.

Serum Endocan Levels Predict Drug-Eluting Stent Restenosis in Patients with Stable Angina Pectoris

Ayhan Küp  1 , Cüneyt Toprak  2 , Emrah Bayam  3 , Servet İzcı  1 , Abdulkadir Uslu  1 , Mehmet Çelık  1 , İsmail Balaban  1 , Sinan Cerşıt  1 , Süleyman Barutçu  4 , Pınar Demir Gündoğmuş  5
Affiliations

Serum Endocan Levels Predict Drug-Eluting Stent Restenosis in Patients with Stable Angina Pectoris

Ayhan Küp et al. Acta Cardiol Sin. 2020 Mar.

Abstract

Background: Endothelial cell-specific molecule 1 (ESM-1 or endocan) is an immunoinflammatory marker strongly associated with inflammation, vascular endothelial dysfunction and atherosclerosis. We explored the relationship between serum endocan concentrations and coronary in-stent restenosis (ISR).

Methods: Fifty consecutive patients with ISR and 50 control subjects were included in this study. Clinical data and angiographic characteristics were collected. Serum endocan concentrations were measured using an enzyme-linked immunosorbent assay.

Results: All included patients were divided into four quartiles based on their concentrations of endocan: quartile 1 (0.62-1.31 ng/mL), quartile 2 (1.33-1.74 ng/mL), quartile 3 (1.75-2.77 ng/mL) and quartile 4 (2.78-4.24 ng/mL). The rates of ISR were 16%, 24%, 68%, and 92%, respectively. The patients in quartile 4 had significantly higher rates of ISR than the other groups (p < 0.001). Logistic regression analysis indicated that endocan concentration [odds ratio = 8.65, 95% confidence interval 3.56-20.94; p < 0.001] was an independent predictor of ISR. Receiver operating characteristic curve analysis was used to explore the relationship between endocan and ISR. Using a cutoff value of 1.625 ng/mL, endocan predicted ISR with a sensitivity of 86% and a specificity of 78%.

Conclusions: Our findings suggest that plasma endocan levels may be a novel biomarker of endothelial dysfunction in patients with ISR.

Keywords: Biomarker; Endocan; Endothelial cell-specific molecule 1; Inflammation.

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Figures

Figure 1
Figure 1
ISR rate stratified by endocan quartiles. ISR, in-stent restenosis.
Figure 2
Figure 2
The receiver-operating characteristics (ROC) curve analysis of endocan for predicting in-stent restenosis.
See this image and copyright information in PMC

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