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Review
. 2016 Jul;11(7):529-534.
doi: 10.2217/fvl-2016-0060. Epub 2016 Jul 1.

Host resilience to emerging coronaviruses

Amanda M Jamieson  1
Affiliations
Review

Host resilience to emerging coronaviruses

Amanda M Jamieson. Future Virol. 2016 Jul.

Abstract

Recently, two coronaviruses, severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, have emerged to cause unusually severe respiratory disease in humans. Currently, there is a lack of effective antiviral treatment options or vaccine available. Given the severity of these outbreaks, and the possibility of additional zoonotic coronaviruses emerging in the near future, the exploration of different treatment strategies is necessary. Disease resilience is the ability of a given host to tolerate an infection, and to return to a state of health. This review focuses on exploring various host resilience mechanisms that could be exploited for treatment of severe acute respiratory syndrome coronavirus, Middle East respiratory syndrome coronavirus and other respiratory viruses that cause acute lung injury and acute respiratory distress syndrome.

Keywords: ALI; ARDS; MERS-CoV; SARS-CoV; coronavirus; disease tolerance; host resilience; pulmonary; respiratory infection; viral pathogenesis.

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Conflict of interest statement

Financial & competing interests disclosure The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.

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