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Review
. 2020 Feb 10;11(9):2540-2551.
doi: 10.7150/jca.37604. eCollection 2020.

Application of metabolomics in the diagnosis of breast cancer: a systematic review

Liqing Yang  1 , Ying Wang  1 , Haishan Cai  1 , Shuang Wang  1 , Yueping Shen  2 , Chaofu Ke  2
Affiliations
Review

Application of metabolomics in the diagnosis of breast cancer: a systematic review

Liqing Yang et al. J Cancer. .

Abstract

Breast cancer (BC) remains the most frequent type of cancer in females worldwide. However, the pathogenesis of BC is still under the cloud, along with the huge challenge of early diagnosis, which is widely acknowledged as the key to a successful therapy. Metabolomics, a newborn innovative technique in recent years, has demonstrated great potential in cancer-related researches. The aim of this review is to look back on clinical and cellular metabolomic studies in the diagnosis of BC over the past decade, and provide a systematic summary of metabolic biomarkers and pathways related to BC diagnosis.

Keywords: Breast Cancer; Diagnosis; Metabolomics.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Systems biology approaches.
Figure 2
Figure 2
Flow chart of the literature search and selection.
Figure 3
Figure 3
Characteristics of clinical studies.
Figure 4
Figure 4
Pathway analysis for clinical significant metabolites.
Figure 5
Figure 5
Characteristics of cellular studies.
Figure 6
Figure 6
Pathway analysis for cellular significant metabolites.
Figure 7
Figure 7
Metabolism in the diagnosis of BC. The red stand for metabolites with hits more than 3, and the green stand for 2-hit frequency metabolites. Abbreviation: G-6-P: glucose-6-phosphate; F-6-P: fructose-6-phosphate; F-1,6-2P: fructose-1, 6-bishosphate; G-3-P: glyceraldehyde-3-phophate; 1,3-DPG: 1,3-diphosphoglyceric acid; 3-PGA: 3-phosphoglycerate; 2-PGA: 2-phosphoglycerate; PEP: phosphoenolpyruvate; DHAP: dihydroxyacetone phosphate; TG: triglyceride; Glycerol-3-P: glycerol-3-phosphate; 1,2-DAG: 1,2-diacylglycerol; PE: phosphatidyl ethanolamine; PC: phosphatidylcholine; CDP DG: cytidine-5'-diphosphate 1,2-diacyl-sn-glycerol; GPC: glycerophosphocholine; MVA: mevalonic acid; HMG CoA: β-hydroxy-β-methylglutaryl- coenzyme A; TCA: tricarboxylic acid.
See this image and copyright information in PMC

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