Making sense of emerging evidence on the non-specific effects of the BCG vaccine on malaria risk and neonatal mortality

Quique Bassat^{1

2

3

4

5}, Gemma Moncunill¹, Carlota Dobaño¹

Affiliations

¹ ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
² Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Maputo, Mozambique.
³ ICREA, Pg. Lluís Companys 23, Barcelona, Spain.
⁴ Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Sant Joan de Déu (University of Barcelona), Barcelona, Spain.
⁵ Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

PMID: 32201627
PMCID: PMC7059422
DOI: 10.1136/bmjgh-2020-002301

Editorial

Making sense of emerging evidence on the non-specific effects of the BCG vaccine on malaria risk and neonatal mortality

Quique Bassat et al. BMJ Glob Health. 2020.

. 2020 Mar 5;5(3):e002301.

doi: 10.1136/bmjgh-2020-002301. eCollection 2020.

Authors

Quique Bassat^{1

2

3

4

5}, Gemma Moncunill¹, Carlota Dobaño¹

Affiliations

¹ ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
² Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Maputo, Mozambique.
³ ICREA, Pg. Lluís Companys 23, Barcelona, Spain.
⁴ Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Sant Joan de Déu (University of Barcelona), Barcelona, Spain.
⁵ Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

PMID: 32201627
PMCID: PMC7059422
DOI: 10.1136/bmjgh-2020-002301

No abstract available

Keywords: epidemiology; malaria; vaccines.

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Conflict of interest statement

Competing interests: None declared.

Comment on

BCG vaccination is associated with reduced malaria prevalence in children under the age of 5 years in sub-Saharan Africa.
Berendsen ML, van Gijzel SW, Smits J, de Mast Q, Aaby P, Benn CS, Netea MG, van der Ven AJ. Berendsen ML, et al. BMJ Glob Health. 2019 Nov 14;4(6):e001862. doi: 10.1136/bmjgh-2019-001862. eCollection 2019. BMJ Glob Health. 2019. PMID: 31798997 Free PMC article.
Seasonal variation in the non-specific effects of BCG vaccination on neonatal mortality: three randomised controlled trials in Guinea-Bissau.
Jensen KJ, Biering-Sørensen S, Ursing J, Kofoed PL, Aaby P, Benn CS. Jensen KJ, et al. BMJ Glob Health. 2020 Mar 5;5(3):e001873. doi: 10.1136/bmjgh-2019-001873. eCollection 2020. BMJ Glob Health. 2020. PMID: 32201619 Free PMC article. Clinical Trial.

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References

1. World Health Organization Immunization factsheet. Available: https://www.who.int/news-room/facts-in-pictures/detail/immunization [Accessed 19 Dec 2019].
1. de Bree LCJ, Koeken VACM, Joosten LAB, et al. . Non-Specific effects of vaccines: current evidence and potential implications. Semin Immunol 2018;39:35–43. 10.1016/j.smim.2018.06.002 - DOI - PubMed
1. Pollard AJ, Finn A, Curtis N. Non-Specific effects of vaccines: plausible and potentially important, but implications uncertain. Arch Dis Child 2017;102:1077–81. 10.1136/archdischild-2015-310282 - DOI - PubMed
1. Blok BA, Arts RJW, van Crevel R, et al. . Trained innate immunity as underlying mechanism for the long-term, nonspecific effects of vaccines. J Leukoc Biol 2015;98:347–56. 10.1189/jlb.5RI0315-096R - DOI - PubMed
1. Netea MG, Joosten LAB, Latz E, et al. . Trained immunity: a program of innate immune memory in health and disease. Science 2016;352:aaf1098 10.1126/science.aaf1098 - DOI - PMC - PubMed

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Making sense of emerging evidence on the non-specific effects of the BCG vaccine on malaria risk and neonatal mortality

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Making sense of emerging evidence on the non-specific effects of the BCG vaccine on malaria risk and neonatal mortality

Authors

Affiliations

Conflict of interest statement

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