Bradycardia, Renal Failure, Atrioventricular-nodal Blocker, Shock, and Hyperkalemia Syndrome Diagnosis and Literature Review
- PMID: 32201662
- PMCID: PMC7075507
- DOI: 10.7759/cureus.6985
Bradycardia, Renal Failure, Atrioventricular-nodal Blocker, Shock, and Hyperkalemia Syndrome Diagnosis and Literature Review
Abstract
The combination of bradycardia, renal failure, atrioventricular (AV)-nodal blocker medications, shock, and hyperkalemia (BRASH) is a new syndrome that is a consequence of a positive loop of bradycardia due to AV-nodal blockers and hyperkalemia secondary to renal insufficiency. We present a case of BRASH syndrome in which the patient on chronic AV-nodal blockers presented with bradycardia, hypotension, underlying kidney dysfunction, and hyperkalemia. The patient was medically managed and discharged upon clinical improvement. The purpose of this report is to highlight the rare cases of BRASH syndrome and improve its management.
Keywords: av nodal blockers; bradycardia; brash syndrome; hyperkalemia; shock.
Copyright © 2020, Sattar et al.
Conflict of interest statement
The authors have declared that no competing interests exist.
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References
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- PulmCrit. BRASH syndrome: bradycardia, renal failure, AV blocker, shock, hyperkalaemia. [Feb;2020 ];https://emcrit.org/pulmcrit/brash-syndrome-bradycardia-renal-failure-av-... 2016 :2016.
-
- Synergistic bradycardia from beta blockers, hyperkalemia, and renal failure. Simmons T, Blazar E. J Emerg Med. 2019;57:41–44. - PubMed
-
- Correlation of iatrogenic mild hyperkalaemia and bradyarrhythmia: a problem of polypharmacy in elderly. Ahmad NH, Tan TL. Med Health-Kuala Lumpur. 2017;12:329–334.
-
- Life-threatening hyperkalemia: a potentially lethal drug combination. Juvet T, Gourineni VC, Ravi S, Zarich SW. https://www.ncbi.nlm.nih.gov/pubmed/24156179. Conn Med. 2013;77:491–493. - PubMed
-
- Junctional bradycardia with verapamil in renal failure-care required even with mild hyperkalaemia. Hegazi MO, Aldabie G, Al-Mutairi S, El Sayed A. J Clin Pharm Ther. 2012;37:726–728. - PubMed
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