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Review
. 2020 Jul 14;24(3):324-331.
doi: 10.5935/1518-0557.20200005.

A critical analysis of the impact of endocrine disruptors as a possible etiology of primary ovarian insufficiency

Cecilia de Souza Monteiro  1 , Erica Becker de Sousa Xavier  1   2 , João Pedro Junqueira Caetano  2 , Ricardo Mello Marinho  2   3
Affiliations
Review

A critical analysis of the impact of endocrine disruptors as a possible etiology of primary ovarian insufficiency

Cecilia de Souza Monteiro et al. JBRA Assist Reprod. .

Abstract

Primary ovarian insufficiency is a cause of infertility that affects about 1% of women under 40 years old, and is considered as idiopathic in 75% of cases. This review aims to carry out a critical synthesis of the knowledge of the chemical agents likely to affect follicular stock in humans and / or animals, by direct toxicity to follicles, or by increasing their recruitments. For the majority of toxic agents, only experimental data are currently available. We propose a strategy to encourage progress in identifying occupational factors responsible for premature ovarian failure.

Keywords: Endocrine disruptor; Follicular atresia; Occupational exposure; Primary ovarian insufficiency.

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Conflict of interest statement

CONFLICT OF INTERESTS

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
Search Flowchart (Adapted fromMoher et al., 2009).
Figure 2
Figure 2
Selection flowchart for papers on the impacts of endocrine disruptors on ovarian physiology (Adapted from Béranger et al., 2012.)
Figure 3
Figure 3
Integrated approach in an exposure assessment study (Adapted fromCarvalho et al. 2017)
See this image and copyright information in PMC

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