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Review
. 2020 May 1;24(2):214-218.
doi: 10.5935/1518-0557.20190082.

Preimplantation Factor (PIF): a peptide with various functions

Fateme Zare  1   2 , Seyed Mohammad Seifati  1 , Mahdi Dehghan-Manshadi  3 , Farzaneh Fesahat  1
Affiliations
Review

Preimplantation Factor (PIF): a peptide with various functions

Fateme Zare et al. JBRA Assist Reprod. .

Abstract

Preimplantation Factor (PIF) is a novel fifteen amino acid linear peptide (MVRIKPGSANKPSDD), which has different biological functions in mammalian species e.g. its role in neuron restoration, pregnancy and related disorders, and also in autoimmune diseases. Since all clinical studies have shown that PIF has both local and systemic effects, it can be considered as an integrated therapy for the treatment of inflammation conditions, along with the prevention of advanced disease. The synthetic PIF (sPIF) analog is a good representative of native PIF action, and it regulates peripheral immune cells to achieve endurance without immune suppression - an effective agent in nonpregnant autoimmune models. This study provides information, from evidence-based studies so far about PIF's different functional aspects.

Keywords: immune system; peptide; pregnancy; preimplantation factor.

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Conflict of interest statement

CONFLICT OF INTEREST

All authors declare no financial conflict of interests.

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References

    1. Anin S, Vince G, Quenby S. Trophoblast invasion. Hum Fertil (Camb) 2004;7:169–174. doi: 10.1080/14647270400006911. - DOI - PubMed
    1. Azar Y, Shainer R, Almogi-Hazan O, Bringer R, Compton SR, Paidas MJ, Barnea ER, Or R. Preimplantation factor reduces graft-versus-host disease by regulating immune response and lowering oxidative stress (murine model) Biol Blood Marrow Transplant. 2013;19:519–528. - PubMed
    1. Barnea E, Lahijani KI, Roussev R, Barnea JD, Coulam CB. Use of lymphocyte platelet binding assay for detecting a preimplantation factor: a quantitative assay. Am J Reprod Immunol. 1994;32:133–138. doi: 10.1111/j.1600-0897.1994.tb01103.x. - DOI - PubMed
    1. Barnea E, Gonzalez Perez RR, Leavis PC. New assays for preimplantation factor and preimplantation factor peptides. Patent WO2003004601A2. 2003 Jan 16; https://patents.google.com/patent/WO2003004601A2/en
    1. Barnea ER. Applying Embryo‐Derived Immune Tolerance to the Treatment of Immune Disorders. Ann N Y Acad Sci. 2007;1110:602–618. doi: 10.1196/annals.1423.064. - DOI - PubMed