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. 1988 Sep;120(1):159-71.
doi: 10.1093/genetics/120.1.159.

Genetic evidence that the sans fille locus is involved in Drosophila sex determination

B Oliver  1 , N Perrimon, A P Mahowald
Affiliations

Genetic evidence that the sans fille locus is involved in Drosophila sex determination

B Oliver et al. Genetics. 1988 Sep.

Abstract

Females homozygous for sans fille1621 (= fs(1)1621) have an abnormal germ line. Instead of producing eggs, the germ-line cells proliferate forming ovarian tumors or excessive numbers of nurse cells. The Sex-lethal gene product(s) regulate the branch point of the dosage compensation and sex determination pathways in the soma. The role of Sex-lethal in the germ line is not clear but the germ line of females homozygous for female sterile Sex-lethal alleles or germ-line clones of loss-of-function alleles are characterized by ovarian tumors. Females heterozygous for sans fille1621 or Sex-lethal are phenotypically wild type with respect to viability and fertility but females trans-heterozygous for sans fille1621 and Sex-lethal show ovarian tumors, somatic sexual transformations, and greatly reduced viability.

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