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. 2020 Apr;30(4):363-365.
doi: 10.1038/s41422-020-0303-z. Epub 2020 Mar 20.

Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice

Fangfang Han #  1 , Xiao Liu #  1 , Chuanfang Chen #  1 , Yinan Liu #  1 , Mingkun Du  1 , Yu Zhou  1 , Yong Liu  1 , Bao-Liang Song  1 , Housheng Hansen He  2   3 , Yan Wang  4
Affiliations

Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice

Fangfang Han et al. Cell Res. 2020 Apr.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. rs1997243 is a non-coding variant that regulates blood cholesterol levels through upregulating GPR146 expression.
a rs1997243 and three other SNPs that have strong LD with rs1997243 are located in the genome active region. b Minor allele of rs1997243 increases its promoter activity. c Minor allele of rs1997243 is significantly associated with increased GPR146 expression in humans. d Targeted activation of rs1997243 site increases GPR146 expression in HepG2 cells. e GPR146 is located on plasma membrane of 293 T cells. f GPR146 responds to heat-inactivated serum and actives CRE activity in HepG2 cells. Part of the cells was treated together with PKA inhibitor H89 (10 μM). g Li-gpr146−/− mice have decreased blood cholesterol levels with normal chow (NC) and high-fat high-cholesterol (HFHC) diets feeding. Samples were collected after overnight fasting (n = 6, female, 10–13 weeks). h Li-gpr146−/− mice are protected from high-fat diet (HFD)-induced hypercholesterolemia. Samples were collected after overnight fasting (n = 7–11, male, 10–12 weeks). i Knocking down gpr146 in adult mice decreases blood cholesterol levels (n = 6, male, 8 weeks). Samples were collected after 4 h fasting in the morning. All data are expressed as means ± SEM and P values were calculated with Student’s test (*P < 0.05, **P < 0.01, ***P < 0.001).
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References

    1. Kathiresan S, et al. BMC Med. Genet. 2007;8:S17. doi: 10.1186/1471-2350-8-S1-S17. - DOI - PMC - PubMed
    1. Weiss LA, Pan L, Abney M, Ober C. Nat. Genet. 2006;38:218–222. doi: 10.1038/ng1726. - DOI - PubMed
    1. Chen L, et al. Science China. Life Sci. 2019;62:1420–1458. doi: 10.1007/s11427-019-1563-3. - DOI - PubMed
    1. Willer CJ, et al. Nat. Genet. 2013;45:1274–1283. doi: 10.1038/ng.2797. - DOI - PMC - PubMed
    1. Liu DJ, et al. Nat. Genet. 2017;49:1758–1766. doi: 10.1038/ng.3977. - DOI - PMC - PubMed

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