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Comment
. 2020 May;17(5):533-535.
doi: 10.1038/s41423-020-0402-2. Epub 2020 Mar 19.

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Meijuan Zheng  1 , Yong Gao  2 , Gang Wang  3 , Guobin Song  3 , Siyu Liu  3 , Dandan Sun  3 , Yuanhong Xu  4 , Zhigang Tian  5   6
Affiliations
Comment

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Meijuan Zheng et al. Cell Mol Immunol. 2020 May.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
NKG2A+ cytotoxic lymphocytes are functionally exhausted in COVID-19 patients. a Absolute number of T cells, CD8+ T cells, and NK cells in the peripheral blood of healthy controls (n = 25) and patients with mild (n = 55) and severe (n = 13) infection with SARS-CoV-2. b Percentages of NKG2A+ NK cells and NKG2A+CD8+ T cells in the peripheral blood of healthy controls (n = 25) and patients infected with SARS-CoV-2 (n = 68). c Expression of intracellular CD107a, IFN-γ, IL-2, and granzyme-B in gated NK cells and CD8+ T cells and percentage of TNF-α+ NK cells in the peripheral blood of patients infected with SARS-CoV-2 and healthy controls. d Total number of T cells, CTLs, and NK cells in the peripheral blood of COVID-19 patients and convalescing patients. e Percentages of NKG2A+ NK cells and NKG2A+ CTL in the peripheral blood of COVID-19 patients and convalescing patients. Data are mean ± SEM. Unpaired/paired two-tailed Student’s t tests were conducted. p < 0.05 was considered significant. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; N.S., not significant
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Comment in

  • NKG2A and COVID-19: another brick in the wall.
    Antonioli L, Fornai M, Pellegrini C, Blandizzi C. Antonioli L, et al. Cell Mol Immunol. 2020 Jun;17(6):672-674. doi: 10.1038/s41423-020-0450-7. Epub 2020 May 7. Cell Mol Immunol. 2020. PMID: 32382127 Free PMC article. No abstract available.

Comment on

  • NKG2A is a NK cell exhaustion checkpoint for HCV persistence.
    Zhang C, Wang XM, Li SR, Twelkmeyer T, Wang WH, Zhang SY, Wang SF, Chen JZ, Jin X, Wu YZ, Chen XW, Wang SD, Niu JQ, Chen HR, Tang H. Zhang C, et al. Nat Commun. 2019 Apr 3;10(1):1507. doi: 10.1038/s41467-019-09212-y. Nat Commun. 2019. PMID: 30944315 Free PMC article.

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References

    1. Zhu N, et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2020;382:727–733. doi: 10.1056/NEJMoa2001017. - DOI - PMC - PubMed
    1. Zhang C, et al. NKG2A is a NK cell exhaustion checkpoint for HCV persistence. Nat. Commun. 2019;10:1507. doi: 10.1038/s41467-019-09212-y. - DOI - PMC - PubMed
    1. Zhou, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature579, 270–273 (2020). - PMC - PubMed
    1. Chen N, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–513. doi: 10.1016/S0140-6736(20)30211-7. - DOI - PMC - PubMed
    1. Li F, et al. Blocking the natural killer cell inhibitory receptor NKG2A increases activity of human natural killer cells and clears hepatitis B virus infection in mice. Gastroenterology. 2013;144:392–401. doi: 10.1053/j.gastro.2012.10.039. - DOI - PubMed

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